Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model

Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with h...

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Main Authors:	Abdul Rahim, Roslina, Badaruddin, Muhammad Taufiq, Ahmed, Qamar Uddin, Muhammad, Siti Aesah @ Naznin
Format:	Monograph
Language:	English
Published:	2017
Subjects:	QP Physiology RA Public aspects of medicine RB Pathology
Online Access:	http://irep.iium.edu.my/57071/ http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf

id	iium-57071
recordtype	eprints
spelling	iium-570712017-05-25T06:39:52Z http://irep.iium.edu.my/57071/ Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aesah @ Naznin QP Physiology RA Public aspects of medicine RB Pathology Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD. 2017-05-25 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf Abdul Rahim, Roslina and Badaruddin, Muhammad Taufiq and Ahmed, Qamar Uddin and Muhammad, Siti Aesah @ Naznin (2017) Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model. Research Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology RA Public aspects of medicine RB Pathology
spellingShingle	QP Physiology RA Public aspects of medicine RB Pathology Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aesah @ Naznin Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
description	Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD.
format	Monograph
author	Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aesah @ Naznin
author_facet	Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aesah @ Naznin
author_sort	Abdul Rahim, Roslina
title	Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_short	Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_full	Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_fullStr	Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_full_unstemmed	Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_sort	nigella sativa oil extracts improves dyslipidaemia in high fat diet (hfd) animal model
publishDate	2017
url	http://irep.iium.edu.my/57071/ http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf
first_indexed	2023-09-18T21:20:37Z
last_indexed	2023-09-18T21:20:37Z
_version_	1777411856799891456

Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model

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