The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei

This study was conducted to evaluate the phytochemical contents and antimalarial properties of the oils extracted from the leaves of Malaysian Plectranthus amboinicus in mice infected with Plasmodium berghei. The essential oils were extracted and prepared by using steam distillation technique and su...

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Main Authors:	Ramli, Norazsida, Syed Ahmad, Pakeer Oothuman, Bakhtiar, Muhammad Taher
Format:	Article
Language:	English English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2017
Subjects:	QK Botany QL Zoology QR355 Virology RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/57223/ http://irep.iium.edu.my/57223/ http://irep.iium.edu.my/57223/2/IMJM-Vol-16-p067-074.pdf http://irep.iium.edu.my/57223/9/57223_The%20antimalarial%20properties%20of%20essential%20oils_Scopus.pdf

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recordtype	eprints
spelling	iium-572232017-06-23T02:58:50Z http://irep.iium.edu.my/57223/ The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, Muhammad Taher QK Botany QL Zoology QR355 Virology RM Therapeutics. Pharmacology This study was conducted to evaluate the phytochemical contents and antimalarial properties of the oils extracted from the leaves of Malaysian Plectranthus amboinicus in mice infected with Plasmodium berghei. The essential oils were extracted and prepared by using steam distillation technique and subjected to phytochemical screening by using GC-MS. Antimalarial activity of different extract doses of the essential oil was tested in vivo in ICR mice infected with Plasmodium berghei (PZZ1/100) during early, established and residual infections. In all, 5 compounds made up 88.34% of total oil and the major chemical compounds were carvacrol (85.14%), thymoquinone (1.65%), terpinen-4-ol (0.70%), octenol (0.62%) and thymol (0.23%). Antimalarial assay showed this essential oil as a potential prophylactic agent with the percentage chemosuppression of 45.23%, 18.28%, 45.38% and 58.26% while treated with 50, 200, 400 and 1000 μL/kg respectively of essential oil and curative agent with percentage of chemo suppression of 54.10%, 47.35%, 56.75% and 65.38% while treated with the above dose of essential oil. Statistically no reduction of parasitemia was calculated for suppressive test. The extract has prophylactic and curative effects on P.berghei in mice. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2017-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57223/2/IMJM-Vol-16-p067-074.pdf application/pdf en http://irep.iium.edu.my/57223/9/57223_The%20antimalarial%20properties%20of%20essential%20oils_Scopus.pdf Ramli, Norazsida and Syed Ahmad, Pakeer Oothuman and Bakhtiar, Muhammad Taher (2017) The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei. The International Medical Journal Malaysia, 16 (1). pp. 67-74. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201/IMJM-Vol-16-p067-074.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QK Botany QL Zoology QR355 Virology RM Therapeutics. Pharmacology
spellingShingle	QK Botany QL Zoology QR355 Virology RM Therapeutics. Pharmacology Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, Muhammad Taher The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
description	This study was conducted to evaluate the phytochemical contents and antimalarial properties of the oils extracted from the leaves of Malaysian Plectranthus amboinicus in mice infected with Plasmodium berghei. The essential oils were extracted and prepared by using steam distillation technique and subjected to phytochemical screening by using GC-MS. Antimalarial activity of different extract doses of the essential oil was tested in vivo in ICR mice infected with Plasmodium berghei (PZZ1/100) during early, established and residual infections. In all, 5 compounds made up 88.34% of total oil and the major chemical compounds were carvacrol (85.14%), thymoquinone (1.65%), terpinen-4-ol (0.70%), octenol (0.62%) and thymol (0.23%). Antimalarial assay showed this essential oil as a potential prophylactic agent with the percentage chemosuppression of 45.23%, 18.28%, 45.38% and 58.26% while treated with 50, 200, 400 and 1000 μL/kg respectively of essential oil and curative agent with percentage of chemo suppression of 54.10%, 47.35%, 56.75% and 65.38% while treated with the above dose of essential oil. Statistically no reduction of parasitemia was calculated for suppressive test. The extract has prophylactic and curative effects on P.berghei in mice.
format	Article
author	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, Muhammad Taher
author_facet	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, Muhammad Taher
author_sort	Ramli, Norazsida
title	The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
title_short	The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
title_full	The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
title_fullStr	The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
title_full_unstemmed	The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei
title_sort	antimalarial properties of essential oils of the leaves of malaysian plectranthus amboinicus (lour) spreng in mice infected with plasmodium berghei
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/57223/ http://irep.iium.edu.my/57223/ http://irep.iium.edu.my/57223/2/IMJM-Vol-16-p067-074.pdf http://irep.iium.edu.my/57223/9/57223_The%20antimalarial%20properties%20of%20essential%20oils_Scopus.pdf
first_indexed	2023-09-18T21:20:51Z
last_indexed	2023-09-18T21:20:51Z
_version_	1777411871095128064

The antimalarial properties of essential oils of the leaves of Malaysian Plectranthus amboinicus (Lour) spreng in mice infected with Plasmodium berghei

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