Enhancement of the immediate release of paracetamol from alginate beads

Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the releas...

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Main Authors:	Hamed, Samah, Ayob, Farah Amalina, Alfatama, Mulham, Doolaanea, Abd Almonem
Format:	Article
Language:	English English
Published:	Innovare Academic Sciences Pvt Ltd 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf

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recordtype	eprints
spelling	iium-572642018-04-20T08:57:54Z http://irep.iium.edu.my/57264/ Enhancement of the immediate release of paracetamol from alginate beads Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem RS Pharmacy and materia medica Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the release in the acidic pH. Methods: The beads were prepared by dropwise paracetamol/alginate suspension in divalent cation solution. Two attempts were used to increase the dissolution of paracetamol in the acidic pH. First attempt was by only changing preparation variables: needle size, alginate viscosity and drug loading using 23 full factorial design. The second approach was by adding excipients like carbopol, tween and polyethylene glycol. The beads were characterized for their size, encapsulation efficiency and release profile. Results: First approach, changing preparation variables without excipient adding, helped to increase the drug release in the acid but to a maximum of 26% using a smaller needle, lower drug loading and higher alginate viscosity. However, optimising the formulation with suitable excipients increased the drug release in the acid to 77.3%. The optimised formulation included carbopol 940 (pH sensitive polymer) and tween 80 (facilitates water entry) in the beads, with using barium chloride instead of calcium chloride together with PEG 400 in the complexing solution. Conclusion: To achieve immediate release of paracetamol from alginate beads in the acidic pH, excipients need to be added. Rational selection of excipients is critical to achieve the desired drug release. Innovare Academic Sciences Pvt Ltd 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf application/pdf en http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf Hamed, Samah and Ayob, Farah Amalina and Alfatama, Mulham and Doolaanea, Abd Almonem (2017) Enhancement of the immediate release of paracetamol from alginate beads. International Journal of Applied Pharmaceutics, 9 (2). pp. 47-51. ISSN 0975-7058 https://innovareacademics.in/journals/index.php/ijap/article/viewFile/15672/10165.pdf 10.22159/ijap.2017v9i2.15672
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem Enhancement of the immediate release of paracetamol from alginate beads
description	Objective: Alginate beads are not soluble in the acid leading to small portion released in the stomach. This may not be favourable for drugs administered for fast action like paracetamol. So, this study was aimed to increase the immediate release of paracetamol from alginate beads, i.e. the release in the acidic pH. Methods: The beads were prepared by dropwise paracetamol/alginate suspension in divalent cation solution. Two attempts were used to increase the dissolution of paracetamol in the acidic pH. First attempt was by only changing preparation variables: needle size, alginate viscosity and drug loading using 23 full factorial design. The second approach was by adding excipients like carbopol, tween and polyethylene glycol. The beads were characterized for their size, encapsulation efficiency and release profile. Results: First approach, changing preparation variables without excipient adding, helped to increase the drug release in the acid but to a maximum of 26% using a smaller needle, lower drug loading and higher alginate viscosity. However, optimising the formulation with suitable excipients increased the drug release in the acid to 77.3%. The optimised formulation included carbopol 940 (pH sensitive polymer) and tween 80 (facilitates water entry) in the beads, with using barium chloride instead of calcium chloride together with PEG 400 in the complexing solution. Conclusion: To achieve immediate release of paracetamol from alginate beads in the acidic pH, excipients need to be added. Rational selection of excipients is critical to achieve the desired drug release.
format	Article
author	Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem
author_facet	Hamed, Samah Ayob, Farah Amalina Alfatama, Mulham Doolaanea, Abd Almonem
author_sort	Hamed, Samah
title	Enhancement of the immediate release of paracetamol from alginate beads
title_short	Enhancement of the immediate release of paracetamol from alginate beads
title_full	Enhancement of the immediate release of paracetamol from alginate beads
title_fullStr	Enhancement of the immediate release of paracetamol from alginate beads
title_full_unstemmed	Enhancement of the immediate release of paracetamol from alginate beads
title_sort	enhancement of the immediate release of paracetamol from alginate beads
publisher	Innovare Academic Sciences Pvt Ltd
publishDate	2017
url	http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/ http://irep.iium.edu.my/57264/1/Enhancement%20of%20the%20immediate%20release%20of%20paracetamol%20from%20alginate%20beads.pdf http://irep.iium.edu.my/57264/7/57264_Enhancement%20of%20the%20immediate%20release_Scopus.pdf
first_indexed	2023-09-18T21:20:55Z
last_indexed	2023-09-18T21:20:55Z
_version_	1777411875617636352

Enhancement of the immediate release of paracetamol from alginate beads

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