Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome

The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and also its combination...

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Main Authors:	Balakrishnan, Theenesh, Zulkifly, Ahmad Hafiz, Sha'ban, Munirah, Mohd Jan, Nurul Hafiza, Ibrahim, Mohd Zulfadzli, Md Nazir, Noorhidayah
Format:	Article
Language:	English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2017
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/1/Abstract-journal-for-IMJM-final-MRS%202017%20theenesh.pdf

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spelling	iium-578892018-07-10T09:36:09Z http://irep.iium.edu.my/57889/ Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Sha'ban, Munirah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Md Nazir, Noorhidayah RD701 Orthopedics The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and also its combination with fibrin. Materials and method: Objectives : 1) To compare biocompatibility and biodegradability of polymer (PLGA + fibrin) with PLGA for intra-articular screw fixation 2) to study the imaging microradiograph) features. We used fabricated PLGA scaffolds in combination with autologous fibrin for an in-vivo prospective research. Total of nine New Zealand White Rabbits (NZWR) were operated and the scaffolds were placed at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6,12 and 24 weeks (three NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. Results: The combination of PLGA and fibrin has better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Conclusion: Biodegradable polymer PLGA with incorporation of fibrin resulted in superior outcome compared to usage of other current biodegradable polymers. Kulliyyah of Medicine, International Islamic University Malaysia 2017-08-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57889/1/Abstract-journal-for-IMJM-final-MRS%202017%20theenesh.pdf Balakrishnan, Theenesh and Zulkifly, Ahmad Hafiz and Sha'ban, Munirah and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli and Md Nazir, Noorhidayah (2017) Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome. The International Medical Journal Malaysia, 16 (supp. 1). p. 30. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201%20Supp%201/Abstract-Book-for-IMJM-final-v2-36.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Sha'ban, Munirah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Md Nazir, Noorhidayah Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
description	The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and also its combination with fibrin. Materials and method: Objectives : 1) To compare biocompatibility and biodegradability of polymer (PLGA + fibrin) with PLGA for intra-articular screw fixation 2) to study the imaging microradiograph) features. We used fabricated PLGA scaffolds in combination with autologous fibrin for an in-vivo prospective research. Total of nine New Zealand White Rabbits (NZWR) were operated and the scaffolds were placed at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6,12 and 24 weeks (three NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. Results: The combination of PLGA and fibrin has better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Conclusion: Biodegradable polymer PLGA with incorporation of fibrin resulted in superior outcome compared to usage of other current biodegradable polymers.
format	Article
author	Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Sha'ban, Munirah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Md Nazir, Noorhidayah
author_facet	Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Sha'ban, Munirah Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Md Nazir, Noorhidayah
author_sort	Balakrishnan, Theenesh
title	Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
title_short	Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
title_full	Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
title_fullStr	Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
title_full_unstemmed	Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome
title_sort	comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (plga) combined with autologous fibrin versus plga for intra-articular screw fixation; an in- vivo study with new zealand white rabbits- the microradiograph outcome
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/ http://irep.iium.edu.my/57889/1/Abstract-journal-for-IMJM-final-MRS%202017%20theenesh.pdf
first_indexed	2023-09-18T21:21:51Z
last_indexed	2023-09-18T21:21:51Z
_version_	1777411934078894080

Comparison of biocompatibility and biodegradability of poly(lactic-co-glycolic acid) (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation; an in- vivo study with New Zealand white rabbits- the microradiograph outcome

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