Neuroendorine tumor in the background of adenocarcinoma of midrectum

Introduction: Synchronous neuroendocrine tumor in the background of midrectal adenocarcinoma is rare. It is a very slow-growing tumor and symptomatic only late in the course of the disease. Case Summary: This is a 60 years old gentleman with no past medical illness presented with persistent lo...

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Main Authors:	Mahno, Noor Ezmas, Ong, David, B, Mohd Nurshamizam, Md Nor, Azmi
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RD Surgery
Online Access:	http://irep.iium.edu.my/58385/ http://irep.iium.edu.my/58385/ http://irep.iium.edu.my/58385/13/58385.pdf http://irep.iium.edu.my/58385/2/poster%20net%20rectum.pdf

id	iium-58385
recordtype	eprints
spelling	iium-583852017-09-26T06:58:32Z http://irep.iium.edu.my/58385/ Neuroendorine tumor in the background of adenocarcinoma of midrectum Mahno, Noor Ezmas Ong, David B, Mohd Nurshamizam Md Nor, Azmi RD Surgery Introduction: Synchronous neuroendocrine tumor in the background of midrectal adenocarcinoma is rare. It is a very slow-growing tumor and symptomatic only late in the course of the disease. Case Summary: This is a 60 years old gentleman with no past medical illness presented with persistent loose stool with mucus for 3 months. Colonoscopy found clinically not obstructed upper rectal tumor and biopsy came back as adenocarcinoma. CEA was not raised. CT scan staging showed no distant metastasis and MRI staging reported as T3N0. Intraoperatively, we found midrectal tumor with mucosal ulceration and small liver nodule at segment V. Low anterior resection encompassed of good oncological resection with covering ileostomy was done. Moderately differentiated adenocarcinoma of midrectum with staging of p T2 N0 Mx. Initially, the pathologist reported as the distal doughnut of the specimen was involved. However, after consultation with few experienced pathologist noted an incidental neuroendocrine tumor, grade 1 at the distal doughnut of the specimen with positive immunohistochemical staining for synaptophysin, chromogranin and CD56. Histologically, there were solid nest and occasional rosette of neoplastic cells confined within the submucosal layer, sparing the overlying mucosa. There was no necrosis or muscularis propria invasion. Mitotic figure is low, around 0-1/10 high power field. The Ki67 proliferative index is about 1%. PET scan was arranged to confirm the suspicious liver nodule to rule out metastasis. Serum chromogranin A was pending. He was arranged for oncology review after the PET scan for further plan. 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/58385/13/58385.pdf application/pdf en http://irep.iium.edu.my/58385/2/poster%20net%20rectum.pdf Mahno, Noor Ezmas and Ong, David and B, Mohd Nurshamizam and Md Nor, Azmi (2015) Neuroendorine tumor in the background of adenocarcinoma of midrectum. In: Coloproctology 2015 International Scientific Meeting, 12th-15th March 2015, Melaka. (Unpublished) http://colorectalmy.org/Coloproctology2015/download/Coloproctology2015_SPAB.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RD Surgery
spellingShingle	RD Surgery Mahno, Noor Ezmas Ong, David B, Mohd Nurshamizam Md Nor, Azmi Neuroendorine tumor in the background of adenocarcinoma of midrectum
description	Introduction: Synchronous neuroendocrine tumor in the background of midrectal adenocarcinoma is rare. It is a very slow-growing tumor and symptomatic only late in the course of the disease. Case Summary: This is a 60 years old gentleman with no past medical illness presented with persistent loose stool with mucus for 3 months. Colonoscopy found clinically not obstructed upper rectal tumor and biopsy came back as adenocarcinoma. CEA was not raised. CT scan staging showed no distant metastasis and MRI staging reported as T3N0. Intraoperatively, we found midrectal tumor with mucosal ulceration and small liver nodule at segment V. Low anterior resection encompassed of good oncological resection with covering ileostomy was done. Moderately differentiated adenocarcinoma of midrectum with staging of p T2 N0 Mx. Initially, the pathologist reported as the distal doughnut of the specimen was involved. However, after consultation with few experienced pathologist noted an incidental neuroendocrine tumor, grade 1 at the distal doughnut of the specimen with positive immunohistochemical staining for synaptophysin, chromogranin and CD56. Histologically, there were solid nest and occasional rosette of neoplastic cells confined within the submucosal layer, sparing the overlying mucosa. There was no necrosis or muscularis propria invasion. Mitotic figure is low, around 0-1/10 high power field. The Ki67 proliferative index is about 1%. PET scan was arranged to confirm the suspicious liver nodule to rule out metastasis. Serum chromogranin A was pending. He was arranged for oncology review after the PET scan for further plan.
format	Conference or Workshop Item
author	Mahno, Noor Ezmas Ong, David B, Mohd Nurshamizam Md Nor, Azmi
author_facet	Mahno, Noor Ezmas Ong, David B, Mohd Nurshamizam Md Nor, Azmi
author_sort	Mahno, Noor Ezmas
title	Neuroendorine tumor in the background of adenocarcinoma of midrectum
title_short	Neuroendorine tumor in the background of adenocarcinoma of midrectum
title_full	Neuroendorine tumor in the background of adenocarcinoma of midrectum
title_fullStr	Neuroendorine tumor in the background of adenocarcinoma of midrectum
title_full_unstemmed	Neuroendorine tumor in the background of adenocarcinoma of midrectum
title_sort	neuroendorine tumor in the background of adenocarcinoma of midrectum
publishDate	2015
url	http://irep.iium.edu.my/58385/ http://irep.iium.edu.my/58385/ http://irep.iium.edu.my/58385/13/58385.pdf http://irep.iium.edu.my/58385/2/poster%20net%20rectum.pdf
first_indexed	2023-09-18T21:22:33Z
last_indexed	2023-09-18T21:22:33Z
_version_	1777411978822680576

Neuroendorine tumor in the background of adenocarcinoma of midrectum

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