An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease

Objectives: To establish the relationship between quality of life (QOL) index scores and clinical indicators of lower limb ischemia. Methods: One hundred seventy-eight patients (108 men, median age 70 years) with femoropopliteal lesions suitable for angioplasty were recruited. Assessments were per...

Full description

Bibliographic Details
Main Authors:	Mazari, Fayyaz Ali Khan, Carradice, Daniel, Abdul Rahman, Mohd Norhisham Azmi, Khan, Junaid A., Mockford, Katherine, Mehta, Tapan, McCollum, Peter T, Chetter, Ian C
Format:	Article
Language:	English
Published:	Elsevier 2010
Subjects:	RD Surgery
Online Access:	http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/1/An%20analysis%20of%20relationship%20between%20quality%20of%20life%20indices%20and%20clinical%20improvement%20following%20intervention%20in%20patients%20with%20intermittent%20claudication%20due%20to%20femoro-popliteal%20disease.pdf

id	iium-58429
recordtype	eprints
spelling	iium-584292017-09-25T07:05:25Z http://irep.iium.edu.my/58429/ An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease Mazari, Fayyaz Ali Khan Carradice, Daniel Abdul Rahman, Mohd Norhisham Azmi Khan, Junaid A. Mockford, Katherine Mehta, Tapan McCollum, Peter T Chetter, Ian C RD Surgery Objectives: To establish the relationship between quality of life (QOL) index scores and clinical indicators of lower limb ischemia. Methods: One hundred seventy-eight patients (108 men, median age 70 years) with femoropopliteal lesions suitable for angioplasty were recruited. Assessments were performed prior to and at 1, 3, 6, and 12 months following intervention (angioplasty and/or supervised exercise program). Clinical indicators of lower limb ischemia (treadmill walking distances, ankle pressures), generic (SF36, EuroQol), and disease-specific (Kings College VascuQol) quality of life questionnaires were analyzed. Correlation analysis was performed for index scores (SF-6D, EQ-5D, VascuQol) and individual domain scores using nonparametric tests. Results: All clinical indicators of lower limb ischemia and quality of life index scores showed a statistically significant improvement as result of intervention (Friedman test, P < .001). Both generic QOL index scores (SF-6D, EQ-5D) showed moderate but statistically significant correlation (Spearman’s rank correlation, P < .001) with treadmill walking distances (SF-6D r � 0.533, EQ-5D r�0.500) and weak but significant correlation to resting and postexercise ankle-brachial pressure index (SF-6D r�0.253, EuroQol r � 0.214). Disease-specific index scores (VascuQol) showed similar moderate correlation to treadmill walking distances (r � 0.584, P < .001) and weak but statistically significant correlation with resting and postexercise ABPI (r � 0.377, P < .001). All index scores showed strong and statistically significant (P<.001) correlation with patient-reported walking distance (SF-6D r� 0.604, EQ-5D r � 0.511, VascuQol r � 0.769). All domains of SF36 showed similar correlation with clinical indicators except general health. The strongest correlation was seen with treadmill walking distances in the domains of physical function (r�0.538) and bodily pain (r � 0.524). Conclusion: All generic and disease-specific QOL scores show statistically significant improvement with angioplasty and/or supervised exercise in patients with claudication due to femoropopliteal atherosclerosis. However, the degree of improvement seen in clinical indicators of lower limb ischemia is not reflected in these scores. These findings support the use of composite outcome measures with mandatory, independent assessment of QOL as an independent outcome measure in intervention studies in these patients. Elsevier 2010-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58429/1/An%20analysis%20of%20relationship%20between%20quality%20of%20life%20indices%20and%20clinical%20improvement%20following%20intervention%20in%20patients%20with%20intermittent%20claudication%20due%20to%20femoro-popliteal%20disease.pdf Mazari, Fayyaz Ali Khan and Carradice, Daniel and Abdul Rahman, Mohd Norhisham Azmi and Khan, Junaid A. and Mockford, Katherine and Mehta, Tapan and McCollum, Peter T and Chetter, Ian C (2010) An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease. Journal of Vascular Surgery, 52. pp. 77-84. ISSN 0741-5214 https://www.journals.elsevier.com/journal-of-vascular-surgery 58429
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD Surgery
spellingShingle	RD Surgery Mazari, Fayyaz Ali Khan Carradice, Daniel Abdul Rahman, Mohd Norhisham Azmi Khan, Junaid A. Mockford, Katherine Mehta, Tapan McCollum, Peter T Chetter, Ian C An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
description	Objectives: To establish the relationship between quality of life (QOL) index scores and clinical indicators of lower limb ischemia. Methods: One hundred seventy-eight patients (108 men, median age 70 years) with femoropopliteal lesions suitable for angioplasty were recruited. Assessments were performed prior to and at 1, 3, 6, and 12 months following intervention (angioplasty and/or supervised exercise program). Clinical indicators of lower limb ischemia (treadmill walking distances, ankle pressures), generic (SF36, EuroQol), and disease-specific (Kings College VascuQol) quality of life questionnaires were analyzed. Correlation analysis was performed for index scores (SF-6D, EQ-5D, VascuQol) and individual domain scores using nonparametric tests. Results: All clinical indicators of lower limb ischemia and quality of life index scores showed a statistically significant improvement as result of intervention (Friedman test, P < .001). Both generic QOL index scores (SF-6D, EQ-5D) showed moderate but statistically significant correlation (Spearman’s rank correlation, P < .001) with treadmill walking distances (SF-6D r � 0.533, EQ-5D r�0.500) and weak but significant correlation to resting and postexercise ankle-brachial pressure index (SF-6D r�0.253, EuroQol r � 0.214). Disease-specific index scores (VascuQol) showed similar moderate correlation to treadmill walking distances (r � 0.584, P < .001) and weak but statistically significant correlation with resting and postexercise ABPI (r � 0.377, P < .001). All index scores showed strong and statistically significant (P<.001) correlation with patient-reported walking distance (SF-6D r� 0.604, EQ-5D r � 0.511, VascuQol r � 0.769). All domains of SF36 showed similar correlation with clinical indicators except general health. The strongest correlation was seen with treadmill walking distances in the domains of physical function (r�0.538) and bodily pain (r � 0.524). Conclusion: All generic and disease-specific QOL scores show statistically significant improvement with angioplasty and/or supervised exercise in patients with claudication due to femoropopliteal atherosclerosis. However, the degree of improvement seen in clinical indicators of lower limb ischemia is not reflected in these scores. These findings support the use of composite outcome measures with mandatory, independent assessment of QOL as an independent outcome measure in intervention studies in these patients.
format	Article
author	Mazari, Fayyaz Ali Khan Carradice, Daniel Abdul Rahman, Mohd Norhisham Azmi Khan, Junaid A. Mockford, Katherine Mehta, Tapan McCollum, Peter T Chetter, Ian C
author_facet	Mazari, Fayyaz Ali Khan Carradice, Daniel Abdul Rahman, Mohd Norhisham Azmi Khan, Junaid A. Mockford, Katherine Mehta, Tapan McCollum, Peter T Chetter, Ian C
author_sort	Mazari, Fayyaz Ali Khan
title	An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
title_short	An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
title_full	An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
title_fullStr	An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
title_full_unstemmed	An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
title_sort	analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
publisher	Elsevier
publishDate	2010
url	http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/ http://irep.iium.edu.my/58429/1/An%20analysis%20of%20relationship%20between%20quality%20of%20life%20indices%20and%20clinical%20improvement%20following%20intervention%20in%20patients%20with%20intermittent%20claudication%20due%20to%20femoro-popliteal%20disease.pdf
first_indexed	2023-09-18T21:22:37Z
last_indexed	2023-09-18T21:22:37Z
_version_	1777411982665711616

An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease

Similar Items