Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults

The aim of this study is to provide normal reference ranges for serum thyroid stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3), antithyroperoxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies in Malaysia. A cross sectional study involving 2190 subjects selected...

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Main Authors:	Shahar, Mohammad Arif, Omar, Ahmad Marzuki, Ab Wahab, Norasyikin, Sukor, Norlela, Kamaruddin, Nor Azmi
Format:	Article
Language:	English
Published:	Korean Thyroid Association 2017
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/58582/ http://irep.iium.edu.my/58582/ http://irep.iium.edu.my/58582/1/IJT%20reference%20range%20for%20TSH.pdf

id	iium-58582
recordtype	eprints
spelling	iium-585822017-10-02T00:55:08Z http://irep.iium.edu.my/58582/ Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC Internal medicine The aim of this study is to provide normal reference ranges for serum thyroid stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3), antithyroperoxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies in Malaysia. A cross sectional study involving 2190 subjects selected from 5 assigned regions which were representative of the socioeconomic and geographical background in Malaysia was performed. The median concentrations of TSH, fT4 and fT3, antiTPO and antiTG antibodies were determined from 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). A reference sub-population of 658 subjects was selected from the disease-free population by excluding those who had detectable thyroid antibodies, or biochemical hypo- or hyperthyroidism. The influence of demographic factors on serum TSH, fT4, fT3 and thyroid antibodies was also analysed. The hormonal assays and thyroid antibodies were performed using chemiluminescent microparticle immunoassays by the Architect and Immulite systems respectively. The median concentrations of thyroid hormones and antibodies among the disease free population were TSH 1.16(0.83,1.61)uIU/mL; fT4 12.98(11.99,13.97)pmol/L; fT3 4.10(3.71,4.48)pmol/L; antiTPO 12.8(<10.0,20.4)IU/mL and antiTG <20.0(<20.0,250.7)IU/mL [expressed as median(5th, 95th centiles)]. For the reference population, the median TSH was 1.14(0.83,1.55)uIU/mL with 0.32 and 3.55uIU/mL being the lower and upper limit of normal respectively. TSH levels did not differ between genders while the Indian ethnic group had higher TSH and fT4 levels with greater number of subjects possessing high antiTPO and antiTG levels albeit both total and disease free populations. As age increases, TSH and antiTPO levels increased, fT3 reduced while fT4 remained unchanged. The reference range for TSH level in the adult population of Malaysia was 0.32 – 3.55uIU/mL. The TSH and antiTPO levels increased and fT3 levels decreased with age across all the ethnic groups indicative of inherent physiological changes that occurred with aging. Korean Thyroid Association 2017-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58582/1/IJT%20reference%20range%20for%20TSH.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and Ab Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2017) Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults. International Journal of Thyroidology, 10 (Supplement 1). S128-S128. ISSN 2384-3799 E-ISSN 2466-1899 http://www.ijthyroid.org/main.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
description	The aim of this study is to provide normal reference ranges for serum thyroid stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3), antithyroperoxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies in Malaysia. A cross sectional study involving 2190 subjects selected from 5 assigned regions which were representative of the socioeconomic and geographical background in Malaysia was performed. The median concentrations of TSH, fT4 and fT3, antiTPO and antiTG antibodies were determined from 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). A reference sub-population of 658 subjects was selected from the disease-free population by excluding those who had detectable thyroid antibodies, or biochemical hypo- or hyperthyroidism. The influence of demographic factors on serum TSH, fT4, fT3 and thyroid antibodies was also analysed. The hormonal assays and thyroid antibodies were performed using chemiluminescent microparticle immunoassays by the Architect and Immulite systems respectively. The median concentrations of thyroid hormones and antibodies among the disease free population were TSH 1.16(0.83,1.61)uIU/mL; fT4 12.98(11.99,13.97)pmol/L; fT3 4.10(3.71,4.48)pmol/L; antiTPO 12.8(<10.0,20.4)IU/mL and antiTG <20.0(<20.0,250.7)IU/mL [expressed as median(5th, 95th centiles)]. For the reference population, the median TSH was 1.14(0.83,1.55)uIU/mL with 0.32 and 3.55uIU/mL being the lower and upper limit of normal respectively. TSH levels did not differ between genders while the Indian ethnic group had higher TSH and fT4 levels with greater number of subjects possessing high antiTPO and antiTG levels albeit both total and disease free populations. As age increases, TSH and antiTPO levels increased, fT3 reduced while fT4 remained unchanged. The reference range for TSH level in the adult population of Malaysia was 0.32 – 3.55uIU/mL. The TSH and antiTPO levels increased and fT3 levels decreased with age across all the ethnic groups indicative of inherent physiological changes that occurred with aging.
format	Article
author	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_facet	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_sort	Shahar, Mohammad Arif
title	Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
title_short	Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
title_full	Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
title_fullStr	Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
title_full_unstemmed	Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults
title_sort	establishing reference ranges for thyroid function and thyroid antibody tests among malaysian adults
publisher	Korean Thyroid Association
publishDate	2017
url	http://irep.iium.edu.my/58582/ http://irep.iium.edu.my/58582/ http://irep.iium.edu.my/58582/1/IJT%20reference%20range%20for%20TSH.pdf
first_indexed	2023-09-18T21:22:52Z
last_indexed	2023-09-18T21:22:52Z
_version_	1777411998199316480

Establishing reference ranges for thyroid function and thyroid antibody tests among Malaysian adults

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