Genetic underpinnings in Alzheimer’s disease – A review
In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorp...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Walter de Gruyter GmbH
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf |
| Summary: | In this review, we discuss the genetic etiologies
of Alzheimer’s disease (AD). Furthermore, we review
genetic links to protein signaling pathways as novel
pharmacological targets to treat AD. Moreover, we also
discuss the clumps of AD-mediated genes according to
their single nucleotide polymorphism mutations. Rigorous
data mining approaches justified the significant role
of genes in AD prevalence. Pedigree analysis and twin
studies suggest that genetic components are part of the
etiology, rather than only being risk factors for AD. The
first autosomal dominant mutation in the amyloid precursor
protein (APP) gene was described in 1991. Later, AD
was also associated with mutated early-onset (presenilin
1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E,
ApoE) genes. Genome-wide association and linkage analysis
studies with identified multiple genomic areas have
implications for the treatment of AD. We conclude this
review with future directions and clinical implications of
genetic research in AD. |
|---|