Genetic underpinnings in Alzheimer’s disease – A review

In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorp...

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Main Authors:	Moustafa, Ahmed A., Hassan, Mubashir, Hewedi, Doaa H., Hewedi, Iman, Garami, Julia K., Al Ashwal, Hany, Zaki, Nazar, Seo, Sung-Yum, Cutsuridis, Vassilis, Angulo, Sergio L., Natesh, Joman Y., Herzallah, Mohammad M., Frydecka, Dorota, Misiak, Błażej, Salama, Mohamed, Mohamed, Wael Mohamed Yousef, El Haj, Mohamad, Hornberger, Michael
Format:	Article
Language:	English English
Published:	Walter de Gruyter GmbH 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf

id	iium-58623
recordtype	eprints
spelling	iium-586232018-04-27T09:18:41Z http://irep.iium.edu.my/58623/ Genetic underpinnings in Alzheimer’s disease – A review Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael R Medicine (General) In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD. Walter de Gruyter GmbH 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf application/pdf en http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf Moustafa, Ahmed A. and Hassan, Mubashir and Hewedi, Doaa H. and Hewedi, Iman and Garami, Julia K. and Al Ashwal, Hany and Zaki, Nazar and Seo, Sung-Yum and Cutsuridis, Vassilis and Angulo, Sergio L. and Natesh, Joman Y. and Herzallah, Mohammad M. and Frydecka, Dorota and Misiak, Błażej and Salama, Mohamed and Mohamed, Wael Mohamed Yousef and El Haj, Mohamad and Hornberger, Michael (2017) Genetic underpinnings in Alzheimer’s disease – A review. Reviews in the Neurosciences, 29 (1). pp. 21-38. ISSN 0334-1763 https://www.degruyter.com/view/j/revneuro.ahead-of-print/revneuro-2017-0036/revneuro-2017-0036.xml?format=INT 10.1515/revneuro-2017-0036
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael Genetic underpinnings in Alzheimer’s disease – A review
description	In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.
format	Article
author	Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael
author_facet	Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael
author_sort	Moustafa, Ahmed A.
title	Genetic underpinnings in Alzheimer’s disease – A review
title_short	Genetic underpinnings in Alzheimer’s disease – A review
title_full	Genetic underpinnings in Alzheimer’s disease – A review
title_fullStr	Genetic underpinnings in Alzheimer’s disease – A review
title_full_unstemmed	Genetic underpinnings in Alzheimer’s disease – A review
title_sort	genetic underpinnings in alzheimer’s disease – a review
publisher	Walter de Gruyter GmbH
publishDate	2017
url	http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf
first_indexed	2023-09-18T21:22:56Z
last_indexed	2023-09-18T21:22:56Z
_version_	1777412002268839936

Genetic underpinnings in Alzheimer’s disease – A review

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