Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route

Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability,...

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Main Authors:	Chowdhury, Hira, Gorain, Bapi, Chatterjee, Bappaditya, Mandal, Uttam Kumar, Sengupta, Pinaki, Tekade, Rakesh
Format:	Article
Language:	English English English English
Published:	Bentham Science 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/1/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features.pdf http://irep.iium.edu.my/58690/2/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_SCOPUS.pdf http://irep.iium.edu.my/58690/3/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_WOS.pdf http://irep.iium.edu.my/58690/4/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_MYRA.pdf

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spelling	iium-586902018-03-20T02:51:23Z http://irep.iium.edu.my/58690/ Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh RS Pharmacy and materia medica Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability. Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization. Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route. Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits. Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration. Bentham Science 2017-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58690/1/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features.pdf application/pdf en http://irep.iium.edu.my/58690/2/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58690/3/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_WOS.pdf application/pdf en http://irep.iium.edu.my/58690/4/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_MYRA.pdf Chowdhury, Hira and Gorain, Bapi and Chatterjee, Bappaditya and Mandal, Uttam Kumar and Sengupta, Pinaki and Tekade, Rakesh (2017) Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route. Current Pharmaceutical Design, 23 (17). pp. 2504-2531. ISSN 1381-6128 E-ISSN 1873-4286 http://www.eurekaselect.com/node/147857/article/pharmacokinetic-and-pharmacodynamic-features-of-nanoemulsion-following-oral-intravenous-topical-and-nasal-route 10.2174/1381612822666161201143600
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
description	Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability. Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization. Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route. Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits. Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration.
format	Article
author	Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh
author_facet	Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh
author_sort	Chowdhury, Hira
title	Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
title_short	Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
title_full	Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
title_fullStr	Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
title_full_unstemmed	Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
title_sort	pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
publisher	Bentham Science
publishDate	2017
url	http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/ http://irep.iium.edu.my/58690/1/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features.pdf http://irep.iium.edu.my/58690/2/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_SCOPUS.pdf http://irep.iium.edu.my/58690/3/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_WOS.pdf http://irep.iium.edu.my/58690/4/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_MYRA.pdf
first_indexed	2023-09-18T21:23:01Z
last_indexed	2023-09-18T21:23:01Z
_version_	1777412007334510592

Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route

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