Histological study on the protective effects of tamarind seed extract on cobra venom in mice

Objective: Tamarind (Tamarindus indica) has been used as a medical plant for treating many human and animal diseases and widely used as a traditional herbal medicine for the treatment of snake bites. The objective of the study is to investigate whether tamarind seed extract (TSE) has neutralizat...

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Main Authors:	Al-Ani, Imad Matloub Dally, Ismail, Soraya, Maung, Khin Maung, Syed Ahmad, Pakeer Oothuman, Abdullah, Sinan Mohamed
Format:	Article
Language:	English English
Published:	Innovare Academic Sciences 2017
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/1/58693_HISTOLOGICAL%20STUDY%20ON%20THE%20PROTECTIVE.pdf http://irep.iium.edu.my/58693/7/Histological%20study%20on%20the%20protective%20effects%20of%20tamarind%20seed%20extract%20on%20cobra%20venom%20in%20mice.pdf

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spelling	iium-586932018-05-16T09:10:37Z http://irep.iium.edu.my/58693/ Histological study on the protective effects of tamarind seed extract on cobra venom in mice Al-Ani, Imad Matloub Dally Ismail, Soraya Maung, Khin Maung Syed Ahmad, Pakeer Oothuman Abdullah, Sinan Mohamed RM Therapeutics. Pharmacology Objective: Tamarind (Tamarindus indica) has been used as a medical plant for treating many human and animal diseases and widely used as a traditional herbal medicine for the treatment of snake bites. The objective of the study is to investigate whether tamarind seed extract (TSE) has neutralization activity on an adverse histological reaction against venoms of the King Cobra. Methods: A total of 20 healthy mature male mice were randomly divided into 4 groups with 5 mice in each. The control group was injected with 1 ml of normal saline. The second group was injected subcutaneously with a single dose of 24.96 µg/20 g King Cobra venom (KCV) solution. The third group was injected with the same dose of KCV solution and 10 mg/20 g of TSE. The fourth group was injected with the same dose of KCV solution and 15 mg/20 g TSE solution. The animals were sacrificed after 24 hrs of injection of the solution. Fragments of muscle, kidney, and liver were fixed in 10% neutral buffered formalin and processed for light microscopical studies. Results: The result showed that TSE reduced the histopathological changes induced by the KCV in the muscles, livers, and kidneys, and the improvement was proportional to the applied dose of the TSE indicating that TSE prevents adverse histological changes in the muscle, liver, and kidney. Conclusion: The present study demonstrated that TSE reduced the histopathological changes in the muscle, liver, and kidney induced by KCV in mice. Innovare Academic Sciences 2017-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58693/1/58693_HISTOLOGICAL%20STUDY%20ON%20THE%20PROTECTIVE.pdf application/pdf en http://irep.iium.edu.my/58693/7/Histological%20study%20on%20the%20protective%20effects%20of%20tamarind%20seed%20extract%20on%20cobra%20venom%20in%20mice.pdf Al-Ani, Imad Matloub Dally and Ismail, Soraya and Maung, Khin Maung and Syed Ahmad, Pakeer Oothuman and Abdullah, Sinan Mohamed (2017) Histological study on the protective effects of tamarind seed extract on cobra venom in mice. Asian Journal of Pharmaceutical and Clinical Research, 10 (10). pp. 301-305. ISSN 0974-2441 E-ISSN 2455-3891 https://innovareacademics.in/journals/index.php/ajpcr/article/view/20040/12622 10.22159/ajpcr.2017.v10i10.20040
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Al-Ani, Imad Matloub Dally Ismail, Soraya Maung, Khin Maung Syed Ahmad, Pakeer Oothuman Abdullah, Sinan Mohamed Histological study on the protective effects of tamarind seed extract on cobra venom in mice
description	Objective: Tamarind (Tamarindus indica) has been used as a medical plant for treating many human and animal diseases and widely used as a traditional herbal medicine for the treatment of snake bites. The objective of the study is to investigate whether tamarind seed extract (TSE) has neutralization activity on an adverse histological reaction against venoms of the King Cobra. Methods: A total of 20 healthy mature male mice were randomly divided into 4 groups with 5 mice in each. The control group was injected with 1 ml of normal saline. The second group was injected subcutaneously with a single dose of 24.96 µg/20 g King Cobra venom (KCV) solution. The third group was injected with the same dose of KCV solution and 10 mg/20 g of TSE. The fourth group was injected with the same dose of KCV solution and 15 mg/20 g TSE solution. The animals were sacrificed after 24 hrs of injection of the solution. Fragments of muscle, kidney, and liver were fixed in 10% neutral buffered formalin and processed for light microscopical studies. Results: The result showed that TSE reduced the histopathological changes induced by the KCV in the muscles, livers, and kidneys, and the improvement was proportional to the applied dose of the TSE indicating that TSE prevents adverse histological changes in the muscle, liver, and kidney. Conclusion: The present study demonstrated that TSE reduced the histopathological changes in the muscle, liver, and kidney induced by KCV in mice.
format	Article
author	Al-Ani, Imad Matloub Dally Ismail, Soraya Maung, Khin Maung Syed Ahmad, Pakeer Oothuman Abdullah, Sinan Mohamed
author_facet	Al-Ani, Imad Matloub Dally Ismail, Soraya Maung, Khin Maung Syed Ahmad, Pakeer Oothuman Abdullah, Sinan Mohamed
author_sort	Al-Ani, Imad Matloub Dally
title	Histological study on the protective effects of tamarind seed extract on cobra venom in mice
title_short	Histological study on the protective effects of tamarind seed extract on cobra venom in mice
title_full	Histological study on the protective effects of tamarind seed extract on cobra venom in mice
title_fullStr	Histological study on the protective effects of tamarind seed extract on cobra venom in mice
title_full_unstemmed	Histological study on the protective effects of tamarind seed extract on cobra venom in mice
title_sort	histological study on the protective effects of tamarind seed extract on cobra venom in mice
publisher	Innovare Academic Sciences
publishDate	2017
url	http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/ http://irep.iium.edu.my/58693/1/58693_HISTOLOGICAL%20STUDY%20ON%20THE%20PROTECTIVE.pdf http://irep.iium.edu.my/58693/7/Histological%20study%20on%20the%20protective%20effects%20of%20tamarind%20seed%20extract%20on%20cobra%20venom%20in%20mice.pdf
first_indexed	2023-09-18T21:23:01Z
last_indexed	2023-09-18T21:23:01Z
_version_	1777412007650131968

Histological study on the protective effects of tamarind seed extract on cobra venom in mice

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