Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses

This study investigated the safety of concurrently administering different therapeutic doses of gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into...

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Main Authors:	Al-Mahmood, Sinan, Abdul Razak, Tariq, Che Abdullah, Shahrin Tarmizi, Nik Ahmad, Nik Nur Fatnoon, Mohamed, Abdul Hadi, Al-Ani, Imad Matloub Dally, Almola, Ehsan M.A.
Format:	Article
Language:	English English
Published:	College of Pharmacists of Buenos Aires Province, Argentina 2017
Subjects:	RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/7/Latin_American_Journal_of_Pharmacy_36_11_page_2278.pdf http://irep.iium.edu.my/58694/13/58964-Safety%20of%20the%20concurrent%20use%20of%20gabapentin-SCOPUS.pdf

id	iium-58694
recordtype	eprints
spelling	iium-586942017-12-08T07:51:44Z http://irep.iium.edu.my/58694/ Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses Al-Mahmood, Sinan Abdul Razak, Tariq Che Abdullah, Shahrin Tarmizi Nik Ahmad, Nik Nur Fatnoon Mohamed, Abdul Hadi Al-Ani, Imad Matloub Dally Almola, Ehsan M.A. RM Therapeutics. Pharmacology RM300 Drugs and their action This study investigated the safety of concurrently administering different therapeutic doses of gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into five groups. Four drug regimens, using therapeutic doses calculated from human doses scaled by body surface area, were administered and any effects on kidney and liver biochemical parameters and histopathology were determined. Concurrent therapeutic administration of GBP and CBZ at high doses may produce adverse effects, but maintaining a moderate dose appears safe and may be appropriate, causing fewer side effects than high doses of a single drug or high dose combination therapy. Considera- tion should be given to the total drug load than to the individual doses of each medication. Combining GBP and CBZ in a specific ratio may enable the doses of each to be reduced, which may reduce adverse effects from combination treatments. College of Pharmacists of Buenos Aires Province, Argentina 2017-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58694/7/Latin_American_Journal_of_Pharmacy_36_11_page_2278.pdf application/pdf en http://irep.iium.edu.my/58694/13/58964-Safety%20of%20the%20concurrent%20use%20of%20gabapentin-SCOPUS.pdf Al-Mahmood, Sinan and Abdul Razak, Tariq and Che Abdullah, Shahrin Tarmizi and Nik Ahmad, Nik Nur Fatnoon and Mohamed, Abdul Hadi and Al-Ani, Imad Matloub Dally and Almola, Ehsan M.A. (2017) Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses. Latin American Journal of Pharmacy, 36 (11). pp. 2278-2284. ISSN 0326-2383 E-ISSN 2362-3853 http://www.latamjpharm.org/resumenes/36/11/LAJOP_36_11_1_20.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RM300 Drugs and their action
spellingShingle	RM Therapeutics. Pharmacology RM300 Drugs and their action Al-Mahmood, Sinan Abdul Razak, Tariq Che Abdullah, Shahrin Tarmizi Nik Ahmad, Nik Nur Fatnoon Mohamed, Abdul Hadi Al-Ani, Imad Matloub Dally Almola, Ehsan M.A. Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
description	This study investigated the safety of concurrently administering different therapeutic doses of gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into five groups. Four drug regimens, using therapeutic doses calculated from human doses scaled by body surface area, were administered and any effects on kidney and liver biochemical parameters and histopathology were determined. Concurrent therapeutic administration of GBP and CBZ at high doses may produce adverse effects, but maintaining a moderate dose appears safe and may be appropriate, causing fewer side effects than high doses of a single drug or high dose combination therapy. Considera- tion should be given to the total drug load than to the individual doses of each medication. Combining GBP and CBZ in a specific ratio may enable the doses of each to be reduced, which may reduce adverse effects from combination treatments.
format	Article
author	Al-Mahmood, Sinan Abdul Razak, Tariq Che Abdullah, Shahrin Tarmizi Nik Ahmad, Nik Nur Fatnoon Mohamed, Abdul Hadi Al-Ani, Imad Matloub Dally Almola, Ehsan M.A.
author_facet	Al-Mahmood, Sinan Abdul Razak, Tariq Che Abdullah, Shahrin Tarmizi Nik Ahmad, Nik Nur Fatnoon Mohamed, Abdul Hadi Al-Ani, Imad Matloub Dally Almola, Ehsan M.A.
author_sort	Al-Mahmood, Sinan
title	Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
title_short	Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
title_full	Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
title_fullStr	Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
title_full_unstemmed	Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
title_sort	safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
publisher	College of Pharmacists of Buenos Aires Province, Argentina
publishDate	2017
url	http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/7/Latin_American_Journal_of_Pharmacy_36_11_page_2278.pdf http://irep.iium.edu.my/58694/13/58964-Safety%20of%20the%20concurrent%20use%20of%20gabapentin-SCOPUS.pdf
first_indexed	2023-09-18T21:23:01Z
last_indexed	2023-09-18T21:23:01Z
_version_	1777412007797981184

Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses

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