Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications

Spider silk contains peptides and biomolecules that able to stimulate and improve conditions of wound healing. In this study, we report the potential use of natural silk from common home spider, Pholcus phalangioides, on human keratinocyte cell line (HaCaT) and teeth pulp stem cell’s proliferation a...

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Main Authors:	Shahbuddin, Munira, Ahmad Puat, Nur Najihah, Mirghani, Mohamed Elwathig Saeed, Ahmad Raus, Raha
Format:	Conference or Workshop Item
Language:	English English English
Published:	Springer Verlag 2016
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/13/58732_Natural%20silk%20of%20Pholcus%20phalangioides_conf.%20article_complete.pdf http://irep.iium.edu.my/58732/2/58732_Natural%20silk%20of%20Pholcus%20phalangioides_SCOPUS.pdf http://irep.iium.edu.my/58732/14/58732_Natural%20silk%20of%20Pholcus%20phalangioides_wos.pdf

id	iium-58732
recordtype	eprints
spelling	iium-587322019-08-25T08:06:12Z http://irep.iium.edu.my/58732/ Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications Shahbuddin, Munira Ahmad Puat, Nur Najihah Mirghani, Mohamed Elwathig Saeed Ahmad Raus, Raha TP248.13 Biotechnology Spider silk contains peptides and biomolecules that able to stimulate and improve conditions of wound healing. In this study, we report the potential use of natural silk from common home spider, Pholcus phalangioides, on human keratinocyte cell line (HaCaT) and teeth pulp stem cell’s proliferation and migration. The aim of this study was to examine the range of silk concentrations and their biological effects on the different type of cells. Our study showed that the silk is biocompatible and stimulated the proliferation of HaCaT and teeth pulp stem cells in a dose dependent manner after 24 and 48 hours. Selective effect of cellular migration was observed when the spider silk did not affect the migration of teeth pulp stem cells but only stimulated the migration of HaCaT after 24 hours. The ability of spider silk to stimulate cellular metabolic activity and migration could benefit research and development of biologically active wound dressings. © International Federation for Medical and Biological Engineering 2016. Springer Verlag 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/58732/13/58732_Natural%20silk%20of%20Pholcus%20phalangioides_conf.%20article_complete.pdf application/pdf en http://irep.iium.edu.my/58732/2/58732_Natural%20silk%20of%20Pholcus%20phalangioides_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58732/14/58732_Natural%20silk%20of%20Pholcus%20phalangioides_wos.pdf Shahbuddin, Munira and Ahmad Puat, Nur Najihah and Mirghani, Mohamed Elwathig Saeed and Ahmad Raus, Raha (2016) Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications. In: International Conference for Innovation in Biomedical Engineering and Life Sciences, ICIBEL 2015, 6th-8th Dec. 2015, Putrajaya. https://link.springer.com/chapter/10.1007/978-981-10-0266-3_45 10.1007/978-981-10-0266-3_45
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Shahbuddin, Munira Ahmad Puat, Nur Najihah Mirghani, Mohamed Elwathig Saeed Ahmad Raus, Raha Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
description	Spider silk contains peptides and biomolecules that able to stimulate and improve conditions of wound healing. In this study, we report the potential use of natural silk from common home spider, Pholcus phalangioides, on human keratinocyte cell line (HaCaT) and teeth pulp stem cell’s proliferation and migration. The aim of this study was to examine the range of silk concentrations and their biological effects on the different type of cells. Our study showed that the silk is biocompatible and stimulated the proliferation of HaCaT and teeth pulp stem cells in a dose dependent manner after 24 and 48 hours. Selective effect of cellular migration was observed when the spider silk did not affect the migration of teeth pulp stem cells but only stimulated the migration of HaCaT after 24 hours. The ability of spider silk to stimulate cellular metabolic activity and migration could benefit research and development of biologically active wound dressings. © International Federation for Medical and Biological Engineering 2016.
format	Conference or Workshop Item
author	Shahbuddin, Munira Ahmad Puat, Nur Najihah Mirghani, Mohamed Elwathig Saeed Ahmad Raus, Raha
author_facet	Shahbuddin, Munira Ahmad Puat, Nur Najihah Mirghani, Mohamed Elwathig Saeed Ahmad Raus, Raha
author_sort	Shahbuddin, Munira
title	Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
title_short	Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
title_full	Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
title_fullStr	Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
title_full_unstemmed	Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications
title_sort	natural silk of pholcus phalangioides, a common home spider species for wound healing applications
publisher	Springer Verlag
publishDate	2016
url	http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/ http://irep.iium.edu.my/58732/13/58732_Natural%20silk%20of%20Pholcus%20phalangioides_conf.%20article_complete.pdf http://irep.iium.edu.my/58732/2/58732_Natural%20silk%20of%20Pholcus%20phalangioides_SCOPUS.pdf http://irep.iium.edu.my/58732/14/58732_Natural%20silk%20of%20Pholcus%20phalangioides_wos.pdf
first_indexed	2023-09-18T21:23:05Z
last_indexed	2023-09-18T21:23:05Z
_version_	1777412011925176320

Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications

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