Clinical and histopathological relevance of helicobacter pylori BabA2 genotype

Introduction: H. pylori BabA is an outer membrane protein that mediates bacterial adherence to the gastric epithelium, triggers several pathways during the course of infection, and thus contributes to the disease development. Considering the variability in the presence of BabA coding gene (babA2)...

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Main Authors:	Elhashima, Tariq, Mahmud, Mohammed Imad A. Mustafa, Mohammad Amjad, Nasser, Harun, Norra, Alani, Imad Matloub Dally
Format:	Article
Language:	English English
Published:	Kulliyyah of Medicine, IIUM, Kuantan 2016
Subjects:	RB Pathology RC Internal medicine
Online Access:	http://irep.iium.edu.my/58833/ http://irep.iium.edu.my/58833/ http://irep.iium.edu.my/58833/1/58833_Clinical%20and%20Histopathological%20Relevance_article.pdf http://irep.iium.edu.my/58833/2/58833_Clinical%20and%20Histopathological%20Relevance_wos.pdf

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recordtype	eprints
spelling	iium-588332017-10-20T03:28:51Z http://irep.iium.edu.my/58833/ Clinical and histopathological relevance of helicobacter pylori BabA2 genotype Elhashima, Tariq Mahmud, Mohammed Imad A. Mustafa Mohammad Amjad, Nasser Harun, Norra Alani, Imad Matloub Dally RB Pathology RC Internal medicine Introduction: H. pylori BabA is an outer membrane protein that mediates bacterial adherence to the gastric epithelium, triggers several pathways during the course of infection, and thus contributes to the disease development. Considering the variability in the presence of BabA coding gene (babA2) among H. pylori clinical strains, the aim of this study was to assess the relationship between the genotype status of H. pylori babA2 and the severity of clinical and histopathological outcomes. Methods: Gastric mucosal biopsy specimens were collected from 30 CLO test-positive patients, 16 with gastritis and 14 with peptic ulcer disease. Polymerase chain reaction was carried out to detect the presence of H. pylori-specific glmM gene and BabA coding gene (babA2). Histopathological examination was performed to evaluate the severity of H. pylori-associated gastric disease according to the Updated Sydney Classification System. Results: The glmM and babA2 genes were present in 100% and 86.7% of the tested H. pylori strains, respectively. Although higher degrees of inflammatory activity and H. pylori density were noted in babA2-positive biopsy specimens, there was no statistically significant association between babA2 genotype status and the severity of gastric disease. Conclusion: The babA2 genotype status of H. pylori may not be considered as a sole marker for determining the infection outcomes. Kulliyyah of Medicine, IIUM, Kuantan 2016-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58833/1/58833_Clinical%20and%20Histopathological%20Relevance_article.pdf application/pdf en http://irep.iium.edu.my/58833/2/58833_Clinical%20and%20Histopathological%20Relevance_wos.pdf Elhashima, Tariq and Mahmud, Mohammed Imad A. Mustafa and Mohammad Amjad, Nasser and Harun, Norra and Alani, Imad Matloub Dally (2016) Clinical and histopathological relevance of helicobacter pylori BabA2 genotype. International Medical Journal Malaysia, 15 (2). pp. 43-49. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2015%20No%202/IMJM-Vol-15-No-2-Pg-043-049.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RB Pathology RC Internal medicine
spellingShingle	RB Pathology RC Internal medicine Elhashima, Tariq Mahmud, Mohammed Imad A. Mustafa Mohammad Amjad, Nasser Harun, Norra Alani, Imad Matloub Dally Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
description	Introduction: H. pylori BabA is an outer membrane protein that mediates bacterial adherence to the gastric epithelium, triggers several pathways during the course of infection, and thus contributes to the disease development. Considering the variability in the presence of BabA coding gene (babA2) among H. pylori clinical strains, the aim of this study was to assess the relationship between the genotype status of H. pylori babA2 and the severity of clinical and histopathological outcomes. Methods: Gastric mucosal biopsy specimens were collected from 30 CLO test-positive patients, 16 with gastritis and 14 with peptic ulcer disease. Polymerase chain reaction was carried out to detect the presence of H. pylori-specific glmM gene and BabA coding gene (babA2). Histopathological examination was performed to evaluate the severity of H. pylori-associated gastric disease according to the Updated Sydney Classification System. Results: The glmM and babA2 genes were present in 100% and 86.7% of the tested H. pylori strains, respectively. Although higher degrees of inflammatory activity and H. pylori density were noted in babA2-positive biopsy specimens, there was no statistically significant association between babA2 genotype status and the severity of gastric disease. Conclusion: The babA2 genotype status of H. pylori may not be considered as a sole marker for determining the infection outcomes.
format	Article
author	Elhashima, Tariq Mahmud, Mohammed Imad A. Mustafa Mohammad Amjad, Nasser Harun, Norra Alani, Imad Matloub Dally
author_facet	Elhashima, Tariq Mahmud, Mohammed Imad A. Mustafa Mohammad Amjad, Nasser Harun, Norra Alani, Imad Matloub Dally
author_sort	Elhashima, Tariq
title	Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
title_short	Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
title_full	Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
title_fullStr	Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
title_full_unstemmed	Clinical and histopathological relevance of helicobacter pylori BabA2 genotype
title_sort	clinical and histopathological relevance of helicobacter pylori baba2 genotype
publisher	Kulliyyah of Medicine, IIUM, Kuantan
publishDate	2016
url	http://irep.iium.edu.my/58833/ http://irep.iium.edu.my/58833/ http://irep.iium.edu.my/58833/1/58833_Clinical%20and%20Histopathological%20Relevance_article.pdf http://irep.iium.edu.my/58833/2/58833_Clinical%20and%20Histopathological%20Relevance_wos.pdf
first_indexed	2023-09-18T21:23:15Z
last_indexed	2023-09-18T21:23:15Z
_version_	1777412022061760512

Clinical and histopathological relevance of helicobacter pylori BabA2 genotype

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