Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited

Abstract: Background: Fibroblasts are the common cells used in clinical regenerative medicine and dentistry. These cells are known to appear heterogeneous in vivo. Previous studies have only investigated the biological properties of these cell subpopulations in vitro. Despite sharing similarity in...

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Main Authors:	Mohd Nor, Nurul Hafizah, Berahim, Zurairah, Ahmad, Azlina, Mokhtar@Makhtar, Khairani Idah, Kannan, Thirumulu Ponnuraj
Format:	Article
Language:	English English English
Published:	Bentham Science Publishers 2017
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/1/Nor%20et%20al%202017-Current%20Stem%20Cell%20Research%20and%20Therapy.pdf http://irep.iium.edu.my/58837/7/58837_Identification%20and%20Characterization%20of%20Intraoral_SCOPUS.pdf http://irep.iium.edu.my/58837/8/58837_Identification%20and%20Characterization%20of%20Intraoral_WOS.pdf

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spelling	iium-588372019-08-22T03:45:24Z http://irep.iium.edu.my/58837/ Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited Mohd Nor, Nurul Hafizah Berahim, Zurairah Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah Kannan, Thirumulu Ponnuraj RK Dentistry Abstract: Background: Fibroblasts are the common cells used in clinical regenerative medicine and dentistry. These cells are known to appear heterogeneous in vivo. Previous studies have only investigated the biological properties of these cell subpopulations in vitro. Despite sharing similarity in their spindle-shaped appearance, previous literatures revealed that they play distinguished functional and biological activities in the body. Objective: This paper highlights the similarities and differences among these cell subpopulations, particularly between intraoral fibroblasts (human periodontal ligament, gingival and oral mucosa fibroblasts) and dermal fibroblasts based on several factors including their morphology, growth and proliferation rate. Results: It could be suggested that each subpopulation of fibroblasts demonstrate different positionspecified gene signatures and responses towards extracellular signals. These dissimilarities are crucial to be taken into consideration to employ specific methodologies in stimulating these cells in vivo. Conclusion: A comparison of the characteristics of these cell subpopulations is desired for identifying appropriate cellular applications. Keywords: Dermal fibroblast, differences, gingival fibroblast, oral mucosa fibroblast, periodontal ligament fibroblast, similarities Bentham Science Publishers 2017-09-29 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58837/1/Nor%20et%20al%202017-Current%20Stem%20Cell%20Research%20and%20Therapy.pdf application/pdf en http://irep.iium.edu.my/58837/7/58837_Identification%20and%20Characterization%20of%20Intraoral_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58837/8/58837_Identification%20and%20Characterization%20of%20Intraoral_WOS.pdf Mohd Nor, Nurul Hafizah and Berahim, Zurairah and Ahmad, Azlina and Mokhtar@Makhtar, Khairani Idah and Kannan, Thirumulu Ponnuraj (2017) Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited. Current Stem Cell Research & Therapy, 12 (8). pp. 1-7. ISSN 1574-888X E-ISSN 2212-3946 https://benthamscience.com/journals/current-stem-cell-research-and-therapy/ 10.2174/1574888X12666170929124621
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RK Dentistry
spellingShingle	RK Dentistry Mohd Nor, Nurul Hafizah Berahim, Zurairah Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah Kannan, Thirumulu Ponnuraj Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
description	Abstract: Background: Fibroblasts are the common cells used in clinical regenerative medicine and dentistry. These cells are known to appear heterogeneous in vivo. Previous studies have only investigated the biological properties of these cell subpopulations in vitro. Despite sharing similarity in their spindle-shaped appearance, previous literatures revealed that they play distinguished functional and biological activities in the body. Objective: This paper highlights the similarities and differences among these cell subpopulations, particularly between intraoral fibroblasts (human periodontal ligament, gingival and oral mucosa fibroblasts) and dermal fibroblasts based on several factors including their morphology, growth and proliferation rate. Results: It could be suggested that each subpopulation of fibroblasts demonstrate different positionspecified gene signatures and responses towards extracellular signals. These dissimilarities are crucial to be taken into consideration to employ specific methodologies in stimulating these cells in vivo. Conclusion: A comparison of the characteristics of these cell subpopulations is desired for identifying appropriate cellular applications. Keywords: Dermal fibroblast, differences, gingival fibroblast, oral mucosa fibroblast, periodontal ligament fibroblast, similarities
format	Article
author	Mohd Nor, Nurul Hafizah Berahim, Zurairah Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah Kannan, Thirumulu Ponnuraj
author_facet	Mohd Nor, Nurul Hafizah Berahim, Zurairah Ahmad, Azlina Mokhtar@Makhtar, Khairani Idah Kannan, Thirumulu Ponnuraj
author_sort	Mohd Nor, Nurul Hafizah
title	Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
title_short	Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
title_full	Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
title_fullStr	Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
title_full_unstemmed	Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited
title_sort	identification and characterization of intraoral and dermal fibroblasts revisited
publisher	Bentham Science Publishers
publishDate	2017
url	http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/ http://irep.iium.edu.my/58837/1/Nor%20et%20al%202017-Current%20Stem%20Cell%20Research%20and%20Therapy.pdf http://irep.iium.edu.my/58837/7/58837_Identification%20and%20Characterization%20of%20Intraoral_SCOPUS.pdf http://irep.iium.edu.my/58837/8/58837_Identification%20and%20Characterization%20of%20Intraoral_WOS.pdf
first_indexed	2023-09-18T21:23:15Z
last_indexed	2023-09-18T21:23:15Z
_version_	1777412022618554368

Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited

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