Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations

Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations

Background and Objectives: Glu298Asp endothelial Nitric Oxide Synthase (eNOS) gene polymorphism results in a reduced bioavailability of Nitric Oxide (NO) & prones to atherosclerosis. Even though there were more than 15 studies conducted on Asian populations investigating the role of this polymor...

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Main Authors: Ibrahim, Wisam Nabeel, Sabria, Muhammed Azali, Muhammad Musa, Nurul Ashikin, Nik Ahmad, Nik Nur Fatnoon, Abdullah, Nor Zamzila, A. Talib, Norlelawati
Format: Article
Language:English
Published: Asian Network for Scientific Information 2017
Subjects:
QP Physiology
RA Public aspects of medicine
Online Access:http://irep.iium.edu.my/58861/
http://irep.iium.edu.my/58861/
http://irep.iium.edu.my/58861/1/JMS.pdf
id iium-58861
recordtype eprints
spelling iium-588612020-01-10T10:48:15Z http://irep.iium.edu.my/58861/ Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations Ibrahim, Wisam Nabeel Sabria, Muhammed Azali Muhammad Musa, Nurul Ashikin Nik Ahmad, Nik Nur Fatnoon Abdullah, Nor Zamzila A. Talib, Norlelawati QP Physiology RA Public aspects of medicine Background and Objectives: Glu298Asp endothelial Nitric Oxide Synthase (eNOS) gene polymorphism results in a reduced bioavailability of Nitric Oxide (NO) & prones to atherosclerosis. Even though there were more than 15 studies conducted on Asian populations investigating the role of this polymorphism in coronary artery disease (CAD), however; the representative data from Malaysia is still not clear. The aim of this study was to assess the association between Glu298Asp polymorphism and CAD through original research with the integration of other studies through meta-analysis approach. Methods: The study included 185 CAD patients and 188 control participants. Polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) assay was used to identify the genotype of the study participants. The results were confirmed by nucleotide sequencing of selected genotypes, and the association with CAD was tested using SPSS version 19 with Chi-square test. Execution of meta-analysis involved 23 Asian case-control studies using Revman meta-analysis software version 5.3. Results: The study has demonstrated a significant association between Glu298Asp genotype variants and CAD patients (p < 0.001). Asp allele was a significant predictor for CAD ([p=0.001, OR=2.186 (1.53-3.125; CI= 95 %)]. Through meta-analysis the combined cohort data showed significant Glu298Asp risk to CAD [p<0.0001, OR=2.41 (1.61-3.59); Heterogeneity test (I2=10%, p=0.33)]. Conclusion: Homozygous Asp genotype of Glu298Asp polymorphism potentiates a risk for CAD. Asian Network for Scientific Information 2017-03-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58861/1/JMS.pdf Ibrahim, Wisam Nabeel and Sabria, Muhammed Azali and Muhammad Musa, Nurul Ashikin and Nik Ahmad, Nik Nur Fatnoon and Abdullah, Nor Zamzila and A. Talib, Norlelawati (2017) Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations. Journal of Medical Sciences, 17 (1). pp. 38-45. ISSN 1682-4474 10.3923/jms.2017.38.45
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QP Physiology
RA Public aspects of medicine
spellingShingle QP Physiology
RA Public aspects of medicine
Ibrahim, Wisam Nabeel
Sabria, Muhammed Azali
Muhammad Musa, Nurul Ashikin
Nik Ahmad, Nik Nur Fatnoon
Abdullah, Nor Zamzila
A. Talib, Norlelawati
Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
description Background and Objectives: Glu298Asp endothelial Nitric Oxide Synthase (eNOS) gene polymorphism results in a reduced bioavailability of Nitric Oxide (NO) & prones to atherosclerosis. Even though there were more than 15 studies conducted on Asian populations investigating the role of this polymorphism in coronary artery disease (CAD), however; the representative data from Malaysia is still not clear. The aim of this study was to assess the association between Glu298Asp polymorphism and CAD through original research with the integration of other studies through meta-analysis approach. Methods: The study included 185 CAD patients and 188 control participants. Polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) assay was used to identify the genotype of the study participants. The results were confirmed by nucleotide sequencing of selected genotypes, and the association with CAD was tested using SPSS version 19 with Chi-square test. Execution of meta-analysis involved 23 Asian case-control studies using Revman meta-analysis software version 5.3. Results: The study has demonstrated a significant association between Glu298Asp genotype variants and CAD patients (p < 0.001). Asp allele was a significant predictor for CAD ([p=0.001, OR=2.186 (1.53-3.125; CI= 95 %)]. Through meta-analysis the combined cohort data showed significant Glu298Asp risk to CAD [p<0.0001, OR=2.41 (1.61-3.59); Heterogeneity test (I2=10%, p=0.33)]. Conclusion: Homozygous Asp genotype of Glu298Asp polymorphism potentiates a risk for CAD.
format Article
author Ibrahim, Wisam Nabeel
Sabria, Muhammed Azali
Muhammad Musa, Nurul Ashikin
Nik Ahmad, Nik Nur Fatnoon
Abdullah, Nor Zamzila
A. Talib, Norlelawati
author_facet Ibrahim, Wisam Nabeel
Sabria, Muhammed Azali
Muhammad Musa, Nurul Ashikin
Nik Ahmad, Nik Nur Fatnoon
Abdullah, Nor Zamzila
A. Talib, Norlelawati
author_sort Ibrahim, Wisam Nabeel
title Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
title_short Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
title_full Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
title_fullStr Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
title_full_unstemmed Endothelial Nitric oxide synthase gene polymorphism and coronary arrtery disease in Asian populations
title_sort endothelial nitric oxide synthase gene polymorphism and coronary arrtery disease in asian populations
publisher Asian Network for Scientific Information
publishDate 2017
url http://irep.iium.edu.my/58861/
http://irep.iium.edu.my/58861/
http://irep.iium.edu.my/58861/1/JMS.pdf
first_indexed 2023-09-18T21:23:18Z
last_indexed 2023-09-18T21:23:18Z
_version_ 1777412025231605760

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