The target and impact of KT/V for Asian ESRD patients on haemodialysis

INTRODUCTION The pathology of renal failure results in the deterioration of multiple physiologic, biochemical, and biologic bodily functions. Haemodialysis (HD) is the main method of therapy of reducing the damages, up to some extent. KT/V has long been used to measure the adequacy of haemodialys...

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Main Authors:	Mohamad Nor, Fariz Safhan, Hamzah, Mohd Hazlan, Seman, Mohd Ramli, MK, Ahmad, Chan, Chee Eng, Draman, Che Rosle, Wan Ali, Wan Ahmad Syahril Rozli
Format:	Article
Language:	English
Published:	John Wiley & Sons, Inc. 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/58941/ http://irep.iium.edu.my/58941/ http://irep.iium.edu.my/58941/6/vasc%20access%20and%20ktv%20ishd.pdf

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spelling	iium-589412018-06-08T09:02:20Z http://irep.iium.edu.my/58941/ The target and impact of KT/V for Asian ESRD patients on haemodialysis Mohamad Nor, Fariz Safhan Hamzah, Mohd Hazlan Seman, Mohd Ramli MK, Ahmad Chan, Chee Eng Draman, Che Rosle Wan Ali, Wan Ahmad Syahril Rozli R Medicine (General) INTRODUCTION The pathology of renal failure results in the deterioration of multiple physiologic, biochemical, and biologic bodily functions. Haemodialysis (HD) is the main method of therapy of reducing the damages, up to some extent. KT/V has long been used to measure the adequacy of haemodialysis, despite its limitations. It is still up to now a very useful and easy tool to measure the adequacy of HD. Earlier studies have also shown that KT/V is related to morbidity and mortality. The current recommended target for dialysis adequacy in HD patients is a KT/V of ≥ 1.2. However this recommendation is mainly based on using data from Western population. Even though there are studies to indicate that adult haemodialysis Asian patients experience similar or better intermediate outcomes compared to the Caucasians and African Americans, there is sparse data on the impact of KT/V on patient outcome in the general Asian haemodialysis population. OBJECTIVE This study is aimed at evaluating the impact of KT/V on patient outcome. METHOD This is a cross sectional study involving newly diagnosed End Stage Renal Disease (ESRD) patients initiating HD in the state of Pahang, Malaysia government dialysis centers between 1 January 2014 and 31 December 2014. Baseline demographics, initial dialysis access, dialysis access after 3 months, serum haemoglobin, albumin, calcium and phosphate levels, infection episodes, all causes hospitalisations and patient survival were recorded. The cohort of patients was divided into 3 groups based on the KT/V after 3 months of HD. RESULTS There were 123 cohorts in which 72 (58.5%) with Kt/V > 1.5 (group A), 31 (25.2%) with Kt/V 1.2 – 1.5 (group B) and 20 (16.3%) with Kt/V < 1.2 (group C). The mean age of our cohorts was 53.2 + 14.2 years old. The mean Kt/V was 1.69 + 0.5. Male patients were higher in group C compared to female patients, (27.3% vs 7.3%, p = 0.009) and the mean Kt/V for female was higher, (1.84 + 0.5 vs 1.57 + 0.4, p = 0.003). Central venous catheter (CVC) was used in 80.5% of cohorts at initiation of HD. After 3 months 60.2% were on arteriovenous fistula (AVF). There is no difference in age, races, initial and 6 months HD vascular access between the 3 groups. Group A has significantly higher serum albumin (39.1 + 3.1 g%) compared to group B (36.3 + 3.9 g%) and group C (34.6 + 3.5 g%) [p < 0.05]. Serum phosphate was higher in Group C (2.25 + 0.4 mmol/L) compared to group B (1.70 + 0.4 mmol/L) and group A (1.50 + 0.4 mmol/L). There were no significant difference in infection episodes, all cause hospitalizations and mortality between the 3 groups CONCLUSION Majority of patients achieved high Kt/V in our study. Increasing Kt/V is associated with better serum albumin and phosphate profile. However the impact on overall patient outcome including mortality is still not clear and may be explained by short duration of study. Further larger scale prospective studies may address the issue better. John Wiley & Sons, Inc. 2015-09-01 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/58941/6/vasc%20access%20and%20ktv%20ishd.pdf Mohamad Nor, Fariz Safhan and Hamzah, Mohd Hazlan and Seman, Mohd Ramli and MK, Ahmad and Chan, Chee Eng and Draman, Che Rosle and Wan Ali, Wan Ahmad Syahril Rozli (2015) The target and impact of KT/V for Asian ESRD patients on haemodialysis. Hemodialysis International, 19 (Supplement 2). S51-S52. E-ISSN 1542-4758 http://onlinelibrary.wiley.com/doi/10.1111/hdi.12368/full
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohamad Nor, Fariz Safhan Hamzah, Mohd Hazlan Seman, Mohd Ramli MK, Ahmad Chan, Chee Eng Draman, Che Rosle Wan Ali, Wan Ahmad Syahril Rozli The target and impact of KT/V for Asian ESRD patients on haemodialysis
description	INTRODUCTION The pathology of renal failure results in the deterioration of multiple physiologic, biochemical, and biologic bodily functions. Haemodialysis (HD) is the main method of therapy of reducing the damages, up to some extent. KT/V has long been used to measure the adequacy of haemodialysis, despite its limitations. It is still up to now a very useful and easy tool to measure the adequacy of HD. Earlier studies have also shown that KT/V is related to morbidity and mortality. The current recommended target for dialysis adequacy in HD patients is a KT/V of ≥ 1.2. However this recommendation is mainly based on using data from Western population. Even though there are studies to indicate that adult haemodialysis Asian patients experience similar or better intermediate outcomes compared to the Caucasians and African Americans, there is sparse data on the impact of KT/V on patient outcome in the general Asian haemodialysis population. OBJECTIVE This study is aimed at evaluating the impact of KT/V on patient outcome. METHOD This is a cross sectional study involving newly diagnosed End Stage Renal Disease (ESRD) patients initiating HD in the state of Pahang, Malaysia government dialysis centers between 1 January 2014 and 31 December 2014. Baseline demographics, initial dialysis access, dialysis access after 3 months, serum haemoglobin, albumin, calcium and phosphate levels, infection episodes, all causes hospitalisations and patient survival were recorded. The cohort of patients was divided into 3 groups based on the KT/V after 3 months of HD. RESULTS There were 123 cohorts in which 72 (58.5%) with Kt/V > 1.5 (group A), 31 (25.2%) with Kt/V 1.2 – 1.5 (group B) and 20 (16.3%) with Kt/V < 1.2 (group C). The mean age of our cohorts was 53.2 + 14.2 years old. The mean Kt/V was 1.69 + 0.5. Male patients were higher in group C compared to female patients, (27.3% vs 7.3%, p = 0.009) and the mean Kt/V for female was higher, (1.84 + 0.5 vs 1.57 + 0.4, p = 0.003). Central venous catheter (CVC) was used in 80.5% of cohorts at initiation of HD. After 3 months 60.2% were on arteriovenous fistula (AVF). There is no difference in age, races, initial and 6 months HD vascular access between the 3 groups. Group A has significantly higher serum albumin (39.1 + 3.1 g%) compared to group B (36.3 + 3.9 g%) and group C (34.6 + 3.5 g%) [p < 0.05]. Serum phosphate was higher in Group C (2.25 + 0.4 mmol/L) compared to group B (1.70 + 0.4 mmol/L) and group A (1.50 + 0.4 mmol/L). There were no significant difference in infection episodes, all cause hospitalizations and mortality between the 3 groups CONCLUSION Majority of patients achieved high Kt/V in our study. Increasing Kt/V is associated with better serum albumin and phosphate profile. However the impact on overall patient outcome including mortality is still not clear and may be explained by short duration of study. Further larger scale prospective studies may address the issue better.
format	Article
author	Mohamad Nor, Fariz Safhan Hamzah, Mohd Hazlan Seman, Mohd Ramli MK, Ahmad Chan, Chee Eng Draman, Che Rosle Wan Ali, Wan Ahmad Syahril Rozli
author_facet	Mohamad Nor, Fariz Safhan Hamzah, Mohd Hazlan Seman, Mohd Ramli MK, Ahmad Chan, Chee Eng Draman, Che Rosle Wan Ali, Wan Ahmad Syahril Rozli
author_sort	Mohamad Nor, Fariz Safhan
title	The target and impact of KT/V for Asian ESRD patients on haemodialysis
title_short	The target and impact of KT/V for Asian ESRD patients on haemodialysis
title_full	The target and impact of KT/V for Asian ESRD patients on haemodialysis
title_fullStr	The target and impact of KT/V for Asian ESRD patients on haemodialysis
title_full_unstemmed	The target and impact of KT/V for Asian ESRD patients on haemodialysis
title_sort	target and impact of kt/v for asian esrd patients on haemodialysis
publisher	John Wiley & Sons, Inc.
publishDate	2015
url	http://irep.iium.edu.my/58941/ http://irep.iium.edu.my/58941/ http://irep.iium.edu.my/58941/6/vasc%20access%20and%20ktv%20ishd.pdf
first_indexed	2023-09-18T21:23:25Z
last_indexed	2023-09-18T21:23:25Z
_version_	1777412033067614208

The target and impact of KT/V for Asian ESRD patients on haemodialysis

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