Imbalanced expression of polycistronic miRNA in acute myeloid leukemia

miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It...

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Main Authors:	Kotaki, Ryutaro, Higuchi, Hiroshi, Ogiya, Daisuke, Katahira, Yasuhiro, Kurosaki, Natsumi, Yukihira, Naoko, Ogata, Jun, Yamamoto, Haruna, Mohamad Alba, Syakira, Azhim, Azran, Kitajima, Tatsuo, Inoue, Shigeaki, Morishita, Kazuhiro, Ono, Koh, Koyama-Nasu, Ryo, Kotani, Ai
Format:	Article
Language:	English English
Published:	Springer International Publishing AG 2017
Subjects:	RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:	http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/1/10.1007%40s12185-017-2314-1.pdf http://irep.iium.edu.my/58944/7/Imbalanced%20expression%20of%20polycistronic%20miRNA%20in%20acute%20myeloid%20leukemia.pdf

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recordtype	eprints
spelling	iium-589442018-01-16T04:14:44Z http://irep.iium.edu.my/58944/ Imbalanced expression of polycistronic miRNA in acute myeloid leukemia Kotaki, Ryutaro Higuchi, Hiroshi Ogiya, Daisuke Katahira, Yasuhiro Kurosaki, Natsumi Yukihira, Naoko Ogata, Jun Yamamoto, Haruna Mohamad Alba, Syakira Azhim, Azran Kitajima, Tatsuo Inoue, Shigeaki Morishita, Kazuhiro Ono, Koh Koyama-Nasu, Ryo Kotani, Ai RC0254 Neoplasms. Tumors. Oncology (including Cancer) miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR-1/miR-133 cluster, is correlative. The expression levels of TDP-43, an RNA-binding protein that has been reported to increase the expression, but inhibits the activity, of miR-1, were not correlated with expression levels of miR-1 in AML cells. Taken together, our observations raise the possibility that the balance of polycistronic miRNAs is regulated post-transcriptionally in a hierarchical manner possibly involving EVI1,suggesting that the deregulation of this balance may play some role in AML cells with high EVI1 expression. Springer International Publishing AG 2017-08-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58944/1/10.1007%40s12185-017-2314-1.pdf application/pdf en http://irep.iium.edu.my/58944/7/Imbalanced%20expression%20of%20polycistronic%20miRNA%20in%20acute%20myeloid%20leukemia.pdf Kotaki, Ryutaro and Higuchi, Hiroshi and Ogiya, Daisuke and Katahira, Yasuhiro and Kurosaki, Natsumi and Yukihira, Naoko and Ogata, Jun and Yamamoto, Haruna and Mohamad Alba, Syakira and Azhim, Azran and Kitajima, Tatsuo and Inoue, Shigeaki and Morishita, Kazuhiro and Ono, Koh and Koyama-Nasu, Ryo and Kotani, Ai (2017) Imbalanced expression of polycistronic miRNA in acute myeloid leukemia. International Journal of Hematology. pp. 1-9. ISSN 0925-5710 E-ISSN 1865-3774 (In Press) https://link.springer.com/article/10.1007/s12185-017-2314-1 10.1007/s12185-017-2314-1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle	RC0254 Neoplasms. Tumors. Oncology (including Cancer) Kotaki, Ryutaro Higuchi, Hiroshi Ogiya, Daisuke Katahira, Yasuhiro Kurosaki, Natsumi Yukihira, Naoko Ogata, Jun Yamamoto, Haruna Mohamad Alba, Syakira Azhim, Azran Kitajima, Tatsuo Inoue, Shigeaki Morishita, Kazuhiro Ono, Koh Koyama-Nasu, Ryo Kotani, Ai Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
description	miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR-1/miR-133 cluster, is correlative. The expression levels of TDP-43, an RNA-binding protein that has been reported to increase the expression, but inhibits the activity, of miR-1, were not correlated with expression levels of miR-1 in AML cells. Taken together, our observations raise the possibility that the balance of polycistronic miRNAs is regulated post-transcriptionally in a hierarchical manner possibly involving EVI1,suggesting that the deregulation of this balance may play some role in AML cells with high EVI1 expression.
format	Article
author	Kotaki, Ryutaro Higuchi, Hiroshi Ogiya, Daisuke Katahira, Yasuhiro Kurosaki, Natsumi Yukihira, Naoko Ogata, Jun Yamamoto, Haruna Mohamad Alba, Syakira Azhim, Azran Kitajima, Tatsuo Inoue, Shigeaki Morishita, Kazuhiro Ono, Koh Koyama-Nasu, Ryo Kotani, Ai
author_facet	Kotaki, Ryutaro Higuchi, Hiroshi Ogiya, Daisuke Katahira, Yasuhiro Kurosaki, Natsumi Yukihira, Naoko Ogata, Jun Yamamoto, Haruna Mohamad Alba, Syakira Azhim, Azran Kitajima, Tatsuo Inoue, Shigeaki Morishita, Kazuhiro Ono, Koh Koyama-Nasu, Ryo Kotani, Ai
author_sort	Kotaki, Ryutaro
title	Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
title_short	Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
title_full	Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
title_fullStr	Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
title_full_unstemmed	Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
title_sort	imbalanced expression of polycistronic mirna in acute myeloid leukemia
publisher	Springer International Publishing AG
publishDate	2017
url	http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/ http://irep.iium.edu.my/58944/1/10.1007%40s12185-017-2314-1.pdf http://irep.iium.edu.my/58944/7/Imbalanced%20expression%20of%20polycistronic%20miRNA%20in%20acute%20myeloid%20leukemia.pdf
first_indexed	2023-09-18T21:23:25Z
last_indexed	2023-09-18T21:23:25Z
_version_	1777412033358069760

Imbalanced expression of polycistronic miRNA in acute myeloid leukemia

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