Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination

The prevalence of hypertension is very common amongst the diabetic patients and is reported as the major cause of mortality in diabetes. Pioglitazone reported to have an ability to alter the blood cholesterol level and cardioprotective efficiency along with its antidiabetic activity. Telmisartan, th...

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Main Authors:	Sengupta, Pinaki Ranjan, Chatterjee, Bappaditya, Pal, Tapan Kumar
Format:	Article
Language:	English English
Published:	Academic Press Inc. 2017
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/12/58971_Assessment%20of%20preclinical%20pharmacokinetics%20and%20acute%20toxicity.pdf http://irep.iium.edu.my/58971/7/58971_Assessment%20of%20preclinical%20pharmacokinetics_scopus.pdf

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recordtype	eprints
spelling	iium-589712018-04-04T08:11:47Z http://irep.iium.edu.my/58971/ Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination Sengupta, Pinaki Ranjan Chatterjee, Bappaditya Pal, Tapan Kumar RS192 Materia Medica-Pharmaceutical Technology The prevalence of hypertension is very common amongst the diabetic patients and is reported as the major cause of mortality in diabetes. Pioglitazone reported to have an ability to alter the blood cholesterol level and cardioprotective efficiency along with its antidiabetic activity. Telmisartan, through activation of PPAR-γ receptor exerts insulin sensitizing property in addition to its primary cardioprotective efficiency. Theoretically, a combination of pioglitazone and telmisartan may be beneficial to effectively control the high blood glucose level and management of coexisting cardiovascular complication in diabetes. The aim of this research was to experimentally evaluate the pharmacokinetic interaction of pioglitazone and telmisartan when are coadministered in rat. Pioglitazone and telmisartan were administered orally as a single dose individually and in combination to the rats. The plasma samples of the pharmacokinetic study were analyzed using a validated LCMS method. The acute toxicity of the combination with a high dose in rats was also evaluated as a part of the determination its safety profile. There was no significant change in pharmacokinetic parameters were resulted due to coadministration of pioglitazone and telmisartan in rat. Absence of major toxicological effect supports the safety of the combination in vivo. Academic Press Inc. 2017-10-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58971/12/58971_Assessment%20of%20preclinical%20pharmacokinetics%20and%20acute%20toxicity.pdf application/pdf en http://irep.iium.edu.my/58971/7/58971_Assessment%20of%20preclinical%20pharmacokinetics_scopus.pdf Sengupta, Pinaki Ranjan and Chatterjee, Bappaditya and Pal, Tapan Kumar (2017) Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination. Regulatory Toxicology and Pharmacology, 91 (na). pp. 151-158. ISSN 0273-2300 E-ISSN 1096-0295 http://www.sciencedirect.com/science/article/pii/S0273230017303446 10.1016/j.yrtph.2017.10.029
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Sengupta, Pinaki Ranjan Chatterjee, Bappaditya Pal, Tapan Kumar Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
description	The prevalence of hypertension is very common amongst the diabetic patients and is reported as the major cause of mortality in diabetes. Pioglitazone reported to have an ability to alter the blood cholesterol level and cardioprotective efficiency along with its antidiabetic activity. Telmisartan, through activation of PPAR-γ receptor exerts insulin sensitizing property in addition to its primary cardioprotective efficiency. Theoretically, a combination of pioglitazone and telmisartan may be beneficial to effectively control the high blood glucose level and management of coexisting cardiovascular complication in diabetes. The aim of this research was to experimentally evaluate the pharmacokinetic interaction of pioglitazone and telmisartan when are coadministered in rat. Pioglitazone and telmisartan were administered orally as a single dose individually and in combination to the rats. The plasma samples of the pharmacokinetic study were analyzed using a validated LCMS method. The acute toxicity of the combination with a high dose in rats was also evaluated as a part of the determination its safety profile. There was no significant change in pharmacokinetic parameters were resulted due to coadministration of pioglitazone and telmisartan in rat. Absence of major toxicological effect supports the safety of the combination in vivo.
format	Article
author	Sengupta, Pinaki Ranjan Chatterjee, Bappaditya Pal, Tapan Kumar
author_facet	Sengupta, Pinaki Ranjan Chatterjee, Bappaditya Pal, Tapan Kumar
author_sort	Sengupta, Pinaki Ranjan
title	Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
title_short	Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
title_full	Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
title_fullStr	Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
title_full_unstemmed	Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
title_sort	assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
publisher	Academic Press Inc.
publishDate	2017
url	http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/ http://irep.iium.edu.my/58971/12/58971_Assessment%20of%20preclinical%20pharmacokinetics%20and%20acute%20toxicity.pdf http://irep.iium.edu.my/58971/7/58971_Assessment%20of%20preclinical%20pharmacokinetics_scopus.pdf
first_indexed	2023-09-18T21:23:27Z
last_indexed	2023-09-18T21:23:27Z
_version_	1777412035258089472

Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination

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