Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet

Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in...

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Main Authors:	Jambocus, Najla Gooda Sahib, Ismail, Amin, Khatib, Alfi, Mahomoodally, Fawzi, Saari, Nazamid, Mumtaz, Muhammad Waseem, Abdul Hamid, Azizah Abdul
Format:	Article
Language:	English
Published:	Taylor and Francis Ltd. 2017
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/1/Jambocabus%20et%20al.%20%282017%29.pdf

id	iium-59002
recordtype	eprints
spelling	iium-590022018-01-31T18:56:27Z http://irep.iium.edu.my/59002/ Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet Jambocus, Najla Gooda Sahib Ismail, Amin Khatib, Alfi Mahomoodally, Fawzi Saari, Nazamid Mumtaz, Muhammad Waseem Abdul Hamid, Azizah Abdul RS403 Materia Medica-Pharmaceutical Chemistry Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile. Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. 1H NMR and LCMS methods were employed for phytochemical profiling of MLE60. Results: The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . 1Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant. Conclusion: MLE60 shows promise as an anti-obesity agents and warrants further research. Taylor and Francis Ltd. 2017-07-27 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59002/1/Jambocabus%20et%20al.%20%282017%29.pdf Jambocus, Najla Gooda Sahib and Ismail, Amin and Khatib, Alfi and Mahomoodally, Fawzi and Saari, Nazamid and Mumtaz, Muhammad Waseem and Abdul Hamid, Azizah Abdul (2017) Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet. Food & Nutrition Research, 61. pp. 1-13. ISSN 1654-6628 E-ISSN 1654-661X http://www.tandfonline.com/doi/full/10.1080/16546628.2017.1338919?scroll=top&needAccess=true 10.1080/16546628.2017.1338919
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Jambocus, Najla Gooda Sahib Ismail, Amin Khatib, Alfi Mahomoodally, Fawzi Saari, Nazamid Mumtaz, Muhammad Waseem Abdul Hamid, Azizah Abdul Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
description	Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile. Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. 1H NMR and LCMS methods were employed for phytochemical profiling of MLE60. Results: The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . 1Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant. Conclusion: MLE60 shows promise as an anti-obesity agents and warrants further research.
format	Article
author	Jambocus, Najla Gooda Sahib Ismail, Amin Khatib, Alfi Mahomoodally, Fawzi Saari, Nazamid Mumtaz, Muhammad Waseem Abdul Hamid, Azizah Abdul
author_facet	Jambocus, Najla Gooda Sahib Ismail, Amin Khatib, Alfi Mahomoodally, Fawzi Saari, Nazamid Mumtaz, Muhammad Waseem Abdul Hamid, Azizah Abdul
author_sort	Jambocus, Najla Gooda Sahib
title	Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
title_short	Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
title_full	Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
title_fullStr	Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
title_full_unstemmed	Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet
title_sort	morinda citrifolia l. leaf extract prevent weight gain in sprague-dawley rats fed a high fat diet
publisher	Taylor and Francis Ltd.
publishDate	2017
url	http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/ http://irep.iium.edu.my/59002/1/Jambocabus%20et%20al.%20%282017%29.pdf
first_indexed	2023-09-18T21:23:31Z
last_indexed	2023-09-18T21:23:31Z
_version_	1777412038951174144

Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet

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