Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities

Introduction: Hepatitis C virus (HCV) genotyping is very important for the clinical management of HCV-infected patients. The aim of this study was to determine the genotypes of HCV-infected patients and to identify their risk factors and comorbidities. Materials and Methods: This was an observationa...

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Main Authors:	Abdul Rahman, Siti Nurul Fazlin, Hamzah, Hairul Aini, Hasmoni, Mohamed Hadzri, Mustafa Mahmoud, Mohammed Imad Al-Deen
Format:	Article
Language:	English English
Published:	International Islamic University Malaysia 2017
Subjects:	QR Microbiology R Medicine (General)
Online Access:	http://irep.iium.edu.my/59085/ http://irep.iium.edu.my/59085/ http://irep.iium.edu.my/59085/1/Fazlin%20IMJM%202017.pdf http://irep.iium.edu.my/59085/3/59085_Study%20of%20hepatitis%20C%20virus%20infection_scopus.pdf

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recordtype	eprints
spelling	iium-590852017-11-06T01:21:25Z http://irep.iium.edu.my/59085/ Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities Abdul Rahman, Siti Nurul Fazlin Hamzah, Hairul Aini Hasmoni, Mohamed Hadzri Mustafa Mahmoud, Mohammed Imad Al-Deen QR Microbiology R Medicine (General) Introduction: Hepatitis C virus (HCV) genotyping is very important for the clinical management of HCV-infected patients. The aim of this study was to determine the genotypes of HCV-infected patients and to identify their risk factors and comorbidities. Materials and Methods: This was an observational, cross sectional study in which forty (40) HCV-infected patients attending Gastroenterology Clinic, Hospital Tengku Ampuan Afzan (HTAA) Kuantan Pahang were recruited for the study, from January to July 2014. Nucleotide sequence analysis of the 5’UTR and NS5B region were performed to identify the viral genotypes. Results: Of the 40 samples, 31 (77.5%) isolates were successfully classified into their genotypes and subtypes; 3a (57.5%), 1a (12.5%), 3b (2.5%) and 1b (2.5%). No genotype 2, 4, 5 and 6 were found in this study. However, there was one mixed-genotype (3a/1a) HCV infection. Risk factors and co-morbidities found in this study include IVDUs, haemodialysis, blood transfusion, surgery and co-infection with HIV. Conclusion: Genotype 3 followed by genotype 1 were the common HCV genotypes found in this study population. Furthermore, the highest risk factors and co-morbidities were IVDUs and co-infection with HIV. International Islamic University Malaysia 2017-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59085/1/Fazlin%20IMJM%202017.pdf application/pdf en http://irep.iium.edu.my/59085/3/59085_Study%20of%20hepatitis%20C%20virus%20infection_scopus.pdf Abdul Rahman, Siti Nurul Fazlin and Hamzah, Hairul Aini and Hasmoni, Mohamed Hadzri and Mustafa Mahmoud, Mohammed Imad Al-Deen (2017) Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities. The International Medical Journal Malaysia, 16 (1). pp. 11-20. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201/IMJM-Vol-16-p011-020.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QR Microbiology R Medicine (General)
spellingShingle	QR Microbiology R Medicine (General) Abdul Rahman, Siti Nurul Fazlin Hamzah, Hairul Aini Hasmoni, Mohamed Hadzri Mustafa Mahmoud, Mohammed Imad Al-Deen Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
description	Introduction: Hepatitis C virus (HCV) genotyping is very important for the clinical management of HCV-infected patients. The aim of this study was to determine the genotypes of HCV-infected patients and to identify their risk factors and comorbidities. Materials and Methods: This was an observational, cross sectional study in which forty (40) HCV-infected patients attending Gastroenterology Clinic, Hospital Tengku Ampuan Afzan (HTAA) Kuantan Pahang were recruited for the study, from January to July 2014. Nucleotide sequence analysis of the 5’UTR and NS5B region were performed to identify the viral genotypes. Results: Of the 40 samples, 31 (77.5%) isolates were successfully classified into their genotypes and subtypes; 3a (57.5%), 1a (12.5%), 3b (2.5%) and 1b (2.5%). No genotype 2, 4, 5 and 6 were found in this study. However, there was one mixed-genotype (3a/1a) HCV infection. Risk factors and co-morbidities found in this study include IVDUs, haemodialysis, blood transfusion, surgery and co-infection with HIV. Conclusion: Genotype 3 followed by genotype 1 were the common HCV genotypes found in this study population. Furthermore, the highest risk factors and co-morbidities were IVDUs and co-infection with HIV.
format	Article
author	Abdul Rahman, Siti Nurul Fazlin Hamzah, Hairul Aini Hasmoni, Mohamed Hadzri Mustafa Mahmoud, Mohammed Imad Al-Deen
author_facet	Abdul Rahman, Siti Nurul Fazlin Hamzah, Hairul Aini Hasmoni, Mohamed Hadzri Mustafa Mahmoud, Mohammed Imad Al-Deen
author_sort	Abdul Rahman, Siti Nurul Fazlin
title	Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
title_short	Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
title_full	Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
title_fullStr	Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
title_full_unstemmed	Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities
title_sort	study of hepatitis c virus infection at a tertiary hospital: genotyping, risk factors and comorbidities
publisher	International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/59085/ http://irep.iium.edu.my/59085/ http://irep.iium.edu.my/59085/1/Fazlin%20IMJM%202017.pdf http://irep.iium.edu.my/59085/3/59085_Study%20of%20hepatitis%20C%20virus%20infection_scopus.pdf
first_indexed	2023-09-18T21:23:39Z
last_indexed	2023-09-18T21:23:39Z
_version_	1777412047306227712

Study of Hepatitis C virus infection at a tertiary hospital: Genotyping, risk factors and comorbidities

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