Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach

Background: Ipomoea aquatica (locally known as “kangkung”) has previously been reported to have hypoglycemic activities on glucose level in diabetes patients. However, the effect of I. aquatica ethanolic extract on the metabolites in the body has remained unknown. Purpose: Our study provides new...

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Main Authors:	Sajak, Azliana Abu bakar, Mediani, Ahmed, Maulidiani, M., Mohd Dom, Nur Sumirah, Machap, Chandradevan, Hamid, Muhajir, Khatib, Alfi, Abas, Faridah
Format:	Article
Language:	English English
Published:	Elsevier 2017
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/1/Sajak%20et%20al.%202017%281%29.pdf http://irep.iium.edu.my/59135/7/59135-Effect%20of%20Ipomoea%20aquatica%20ethanolic%20extract%20in%20streptozotocin-SCOPUS.pdf

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spelling	iium-591352018-04-19T08:42:07Z http://irep.iium.edu.my/59135/ Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach Sajak, Azliana Abu bakar Mediani, Ahmed Maulidiani, M. Mohd Dom, Nur Sumirah Machap, Chandradevan Hamid, Muhajir Khatib, Alfi Abas, Faridah RS403 Materia Medica-Pharmaceutical Chemistry Background: Ipomoea aquatica (locally known as “kangkung”) has previously been reported to have hypoglycemic activities on glucose level in diabetes patients. However, the effect of I. aquatica ethanolic extract on the metabolites in the body has remained unknown. Purpose: Our study provides new insights on the changes of endogenous metabolites causes by I. aquatica ethanolic extract and improves the understanding with regard of therapeutic efficacy and mechanism of I. aquatica ethanolic extract. Methods: By using a combination of 1H nuclear magnetic resonance (NMR) with multivariate analysis (MVDA), the changes of metabolites due to I. aquatica ethanolic extract administration in obese diabetic-induced Sprague Dawley rats (OB+STZ+IA) were identified. Results: The results suggested 19 potential biomarkers with variable importance projections (VIP) above 0.5, which include creatine/creatinine, glucose, creatinine, citrate, carnitine, 2- oxoglutarate, succinate, hippurate, leucine, 1-methylnicotinamice (MNA), taurine, 3- hydroxybutyrate (3-HB), tryptophan, lysine, trigonelline, allantoin, formate, acetoacetate (AcAc) and dimethylamine. From the changes in the metabolites, the affected pathways and aspects of metabolism were identified. Conclusion: I. aquatica ethanolic extract manages to increase metabolite levels such as creatinine/creatine, carnitine, MNA, trigonelline, leucine, lysine, 3-HB and decreases metabolite levels, including glucose and tricarboxylic acid (TCA) intermediates. This implies capabilities of I. aquatica ethanolic extract promoting glycolysis, gut microbiota and nicotinate/nicotinamide metabolism, improving the glomerular filtration rate (GFR) and reducing the β-oxidation rate. However, the administration of I. aquatica ethanolic extract has several drawbacks, such as unimproved changes in amino acid metabolism, especially in reducing branched chain amino acid (BCAA) synthesis pathways and lipid metabolism Elsevier 2017-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59135/1/Sajak%20et%20al.%202017%281%29.pdf application/pdf en http://irep.iium.edu.my/59135/7/59135-Effect%20of%20Ipomoea%20aquatica%20ethanolic%20extract%20in%20streptozotocin-SCOPUS.pdf Sajak, Azliana Abu bakar and Mediani, Ahmed and Maulidiani, M. and Mohd Dom, Nur Sumirah and Machap, Chandradevan and Hamid, Muhajir and Khatib, Alfi and Abas, Faridah (2017) Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach. Phytomedicine, 36. pp. 201-209. ISSN 0944-7113 E-ISSN 1618-095X http://www.sciencedirect.com/science/article/pii/S0944711317301514 10.1016/j.phymed.2017.10.011
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Sajak, Azliana Abu bakar Mediani, Ahmed Maulidiani, M. Mohd Dom, Nur Sumirah Machap, Chandradevan Hamid, Muhajir Khatib, Alfi Abas, Faridah Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
description	Background: Ipomoea aquatica (locally known as “kangkung”) has previously been reported to have hypoglycemic activities on glucose level in diabetes patients. However, the effect of I. aquatica ethanolic extract on the metabolites in the body has remained unknown. Purpose: Our study provides new insights on the changes of endogenous metabolites causes by I. aquatica ethanolic extract and improves the understanding with regard of therapeutic efficacy and mechanism of I. aquatica ethanolic extract. Methods: By using a combination of 1H nuclear magnetic resonance (NMR) with multivariate analysis (MVDA), the changes of metabolites due to I. aquatica ethanolic extract administration in obese diabetic-induced Sprague Dawley rats (OB+STZ+IA) were identified. Results: The results suggested 19 potential biomarkers with variable importance projections (VIP) above 0.5, which include creatine/creatinine, glucose, creatinine, citrate, carnitine, 2- oxoglutarate, succinate, hippurate, leucine, 1-methylnicotinamice (MNA), taurine, 3- hydroxybutyrate (3-HB), tryptophan, lysine, trigonelline, allantoin, formate, acetoacetate (AcAc) and dimethylamine. From the changes in the metabolites, the affected pathways and aspects of metabolism were identified. Conclusion: I. aquatica ethanolic extract manages to increase metabolite levels such as creatinine/creatine, carnitine, MNA, trigonelline, leucine, lysine, 3-HB and decreases metabolite levels, including glucose and tricarboxylic acid (TCA) intermediates. This implies capabilities of I. aquatica ethanolic extract promoting glycolysis, gut microbiota and nicotinate/nicotinamide metabolism, improving the glomerular filtration rate (GFR) and reducing the β-oxidation rate. However, the administration of I. aquatica ethanolic extract has several drawbacks, such as unimproved changes in amino acid metabolism, especially in reducing branched chain amino acid (BCAA) synthesis pathways and lipid metabolism
format	Article
author	Sajak, Azliana Abu bakar Mediani, Ahmed Maulidiani, M. Mohd Dom, Nur Sumirah Machap, Chandradevan Hamid, Muhajir Khatib, Alfi Abas, Faridah
author_facet	Sajak, Azliana Abu bakar Mediani, Ahmed Maulidiani, M. Mohd Dom, Nur Sumirah Machap, Chandradevan Hamid, Muhajir Khatib, Alfi Abas, Faridah
author_sort	Sajak, Azliana Abu bakar
title	Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
title_short	Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
title_full	Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
title_fullStr	Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
title_full_unstemmed	Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach
title_sort	effect of ipomoea aquatica ethanolic extract in streptozotocin (stz) induced diabetic rats via 1h nmr-based metabolomics approach
publisher	Elsevier
publishDate	2017
url	http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/ http://irep.iium.edu.my/59135/1/Sajak%20et%20al.%202017%281%29.pdf http://irep.iium.edu.my/59135/7/59135-Effect%20of%20Ipomoea%20aquatica%20ethanolic%20extract%20in%20streptozotocin-SCOPUS.pdf
first_indexed	2023-09-18T21:23:43Z
last_indexed	2023-09-18T21:23:43Z
_version_	1777412052303740928

Effect of Ipomoea aquatica ethanolic extract in streptozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach

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