Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion

Objectives: Class III malocclusion is a dominant inherited, slowly progressive dento-skeletal disharmony. It is characterized by over growth of mandible, stunted growth of maxilla, or a combination of both. The aetiology of class III malocclusion and the role of genes in this phenotype remain indis...

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Main Authors:	Nowrin, Shifat A, Basri, Rehana, Alam, Mohammad Khursheed, Jaafar, Saidi, Mokhtar@Makhtar, Khairani Idah
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/59481/ http://irep.iium.edu.my/59481/ http://irep.iium.edu.my/59481/1/59481_Genetic%20Mutation.pdf

id	iium-59481
recordtype	eprints
spelling	iium-594812017-11-21T02:09:37Z http://irep.iium.edu.my/59481/ Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion Nowrin, Shifat A Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah RK Dentistry Objectives: Class III malocclusion is a dominant inherited, slowly progressive dento-skeletal disharmony. It is characterized by over growth of mandible, stunted growth of maxilla, or a combination of both. The aetiology of class III malocclusion and the role of genes in this phenotype remain indistinct. The main objective of this study was to determine the DUSP6 gene mutation in three generations of a Malaysian Malay family having class III malocclusion and to conduct their cephalometric analyses. Methods: Genetic analyses of DUSP6 gene were carried out in a family with three individuals representing three generations 30 healthy control. Cephalometric radiographs were obtained from class III malocclusion subjects and pre-determined cephalometric linear and angular measurements were performed using Romexis software. t-test was used to analyse the cephalometric measurements compared with the cephalometric norm for class III malocclusion in Malaysia. Results: a heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in all three members of the family with class III malocclusion. Whereas, no mutation found in control group. t-tests showed significant differences in angular measurements Co-Gn-B and SN-MP variables in mutation group compared to the class III malocclusion norm. Conclusions: The outcome of this study broadened the mutation spectrum of class III malocclusion and the importance of DUSP6 gene in craniofacial morphology. 2017-03-18 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/59481/1/59481_Genetic%20Mutation.pdf Nowrin, Shifat A and Basri, Rehana and Alam, Mohammad Khursheed and Jaafar, Saidi and Mokhtar@Makhtar, Khairani Idah (2017) Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion. In: 16th Annual Scientific Meeting & 18th Annual General Meeting of Malaysian Section IADR, 18th March 2017, Armada Hotel, Petaling Jaya, Selangor. (Unpublished) http://www.malseciadr.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Nowrin, Shifat A Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
description	Objectives: Class III malocclusion is a dominant inherited, slowly progressive dento-skeletal disharmony. It is characterized by over growth of mandible, stunted growth of maxilla, or a combination of both. The aetiology of class III malocclusion and the role of genes in this phenotype remain indistinct. The main objective of this study was to determine the DUSP6 gene mutation in three generations of a Malaysian Malay family having class III malocclusion and to conduct their cephalometric analyses. Methods: Genetic analyses of DUSP6 gene were carried out in a family with three individuals representing three generations 30 healthy control. Cephalometric radiographs were obtained from class III malocclusion subjects and pre-determined cephalometric linear and angular measurements were performed using Romexis software. t-test was used to analyse the cephalometric measurements compared with the cephalometric norm for class III malocclusion in Malaysia. Results: a heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in all three members of the family with class III malocclusion. Whereas, no mutation found in control group. t-tests showed significant differences in angular measurements Co-Gn-B and SN-MP variables in mutation group compared to the class III malocclusion norm. Conclusions: The outcome of this study broadened the mutation spectrum of class III malocclusion and the importance of DUSP6 gene in craniofacial morphology.
format	Conference or Workshop Item
author	Nowrin, Shifat A Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah
author_facet	Nowrin, Shifat A Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah
author_sort	Nowrin, Shifat A
title	Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
title_short	Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
title_full	Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
title_fullStr	Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
title_full_unstemmed	Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion
title_sort	genetic mutation and its effect on craniofacial morphology in malaysian family with class iii malocclusion
publishDate	2017
url	http://irep.iium.edu.my/59481/ http://irep.iium.edu.my/59481/ http://irep.iium.edu.my/59481/1/59481_Genetic%20Mutation.pdf
first_indexed	2023-09-18T21:24:16Z
last_indexed	2023-09-18T21:24:16Z
_version_	1777412086512484352

Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion

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