Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-jB signaling and IL-8 expression
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. The transcription factor NF-κB is overexpressed in human MB and is a critical factor for MB tumor growth. NF-κB is known to regulate the expression of interleukin-8 (IL-8), the chemokine that enhances cancer cell growth and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Springer US
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/59658/ http://irep.iium.edu.my/59658/ http://irep.iium.edu.my/59658/ http://irep.iium.edu.my/59658/1/Thymoquinone%20inhibits%20growth%20of%20human%20medulloblastoma%20cells%20by%20inducing%20oxidative%20stress%20and%20caspase-dependent%20apoptosis%20while%20suppressing%20NF-%CE%BAB%20signaling%20and%20IL-8%20expression.pdf http://irep.iium.edu.my/59658/7/59658_Thymoquinone%20inhibits%20growth%20of%20human_SCOPUS.pdf |