Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia

Use of pesticides has been linked to neurobehavioral deficits among exposed workers. Organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases in Malaysia with a comprehensive spraying programme operated since the 1950s. This project aims to estimate workers’ lif...

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Main Authors:	Yusof, Muhammad Zubir, Semple, Sean, Cherrie, John W., Samsuddin, Niza
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RA0421 Public health. Hygiene. Preventive Medicine
Online Access:	http://irep.iium.edu.my/59889/ http://irep.iium.edu.my/59889/1/Abstract.pdf

id	iium-59889
recordtype	eprints
spelling	iium-598892018-01-23T03:11:33Z http://irep.iium.edu.my/59889/ Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia Yusof, Muhammad Zubir Semple, Sean Cherrie, John W. Samsuddin, Niza RA0421 Public health. Hygiene. Preventive Medicine Use of pesticides has been linked to neurobehavioral deficits among exposed workers. Organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases in Malaysia with a comprehensive spraying programme operated since the 1950s. This project aims to estimate workers’ lifetime exposure to pesticides using current measurements and retrospective exposure reconstruction methods. A total of 160 workers who had regular contact with pesticides and 179 office-based workers were recruited to the study. Information on past exposure and job tasks were collected through questionnaire and occupational history interview to help reconstruct workers’ historical exposures Personal inhalation and dermal exposure measurement were also carried out to evaluate current pesticide exposure. Subjective inhalation exposure modelling using information on the determinants of exposure was used to estimate current exposures and compare these to measured values for calibration of the model. Total lifetime cumulative exposure was then assessed for each worker. The mean age was 30 ± 8 years for mosquito control workers and 31 ± 8 years for office based workers. The highest current level of airborne concentration was identified during thermal spraying and mixing by using organophosphates (Thermal spraying = 0.34 mg/m3; and Mixing = 0.18 mg/m3). Total cumulative pesticides inhalation exposure ranged from 0.0002 to 8.91 OEL.years with a median value of 0.96 (IQR= 0.32 – 1.97). General worker aka ‘Fogger’ had the highest estimated cumulative inhalation exposure (median=1.31 OEL.years, IQR = 0.72 – 2.25). Years of working with pesticides was a moderate predictor of lifetime cumulative exposure as indicated by a Spearman’s correlation coefficient of 0.63. A model to estimate the exposure and uptake of pesticide through the skin was also used. This both inhalation and dermal models were used to allow the estimation of combined pesticide exposure for each exposed worker to explore its relationship with neurobehavioral performance. The analysis for dermal and combined exposure are still underway and the final results will be presented during symposium. 2015-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/59889/1/Abstract.pdf Yusof, Muhammad Zubir and Semple, Sean and Cherrie, John W. and Samsuddin, Niza (2015) Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia. In: International Society of Exposure science 25th Annual Meeting, 18-22 October 2015, Nevada, USA. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle	RA0421 Public health. Hygiene. Preventive Medicine Yusof, Muhammad Zubir Semple, Sean Cherrie, John W. Samsuddin, Niza Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
description	Use of pesticides has been linked to neurobehavioral deficits among exposed workers. Organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases in Malaysia with a comprehensive spraying programme operated since the 1950s. This project aims to estimate workers’ lifetime exposure to pesticides using current measurements and retrospective exposure reconstruction methods. A total of 160 workers who had regular contact with pesticides and 179 office-based workers were recruited to the study. Information on past exposure and job tasks were collected through questionnaire and occupational history interview to help reconstruct workers’ historical exposures Personal inhalation and dermal exposure measurement were also carried out to evaluate current pesticide exposure. Subjective inhalation exposure modelling using information on the determinants of exposure was used to estimate current exposures and compare these to measured values for calibration of the model. Total lifetime cumulative exposure was then assessed for each worker. The mean age was 30 ± 8 years for mosquito control workers and 31 ± 8 years for office based workers. The highest current level of airborne concentration was identified during thermal spraying and mixing by using organophosphates (Thermal spraying = 0.34 mg/m3; and Mixing = 0.18 mg/m3). Total cumulative pesticides inhalation exposure ranged from 0.0002 to 8.91 OEL.years with a median value of 0.96 (IQR= 0.32 – 1.97). General worker aka ‘Fogger’ had the highest estimated cumulative inhalation exposure (median=1.31 OEL.years, IQR = 0.72 – 2.25). Years of working with pesticides was a moderate predictor of lifetime cumulative exposure as indicated by a Spearman’s correlation coefficient of 0.63. A model to estimate the exposure and uptake of pesticide through the skin was also used. This both inhalation and dermal models were used to allow the estimation of combined pesticide exposure for each exposed worker to explore its relationship with neurobehavioral performance. The analysis for dermal and combined exposure are still underway and the final results will be presented during symposium.
format	Conference or Workshop Item
author	Yusof, Muhammad Zubir Semple, Sean Cherrie, John W. Samsuddin, Niza
author_facet	Yusof, Muhammad Zubir Semple, Sean Cherrie, John W. Samsuddin, Niza
author_sort	Yusof, Muhammad Zubir
title	Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
title_short	Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
title_full	Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
title_fullStr	Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
title_full_unstemmed	Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia
title_sort	estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in malaysia
publishDate	2015
url	http://irep.iium.edu.my/59889/ http://irep.iium.edu.my/59889/1/Abstract.pdf
first_indexed	2023-09-18T21:24:54Z
last_indexed	2023-09-18T21:24:54Z
_version_	1777412125986127872

Estimating lifetime pesticide exposure and neurobehavioral performance among mosquito control workers in Malaysia

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