GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method

Context: Syzygium polyanthum has been traditionally formulated by the folklore for the treatment of diseases including diarrhea, rheumatism, diabetes mellitus, hypercholesterolemia, hypertension, gastritis and hyperuricemia. Normally, its phytochemicals are always extracted using solvent, maceration...

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Main Authors:	Abd Rahim, Erlena Nor Asmira, Ismail, Azlini, Omar, Muhammad Nor, Rahmat, Umi Nadhirah, Wan Ahmad, Wan Amir Nizam
Format:	Article
Language:	English English
Published:	Pharmacognosy Network Worldwide 2018
Subjects:	Q Science (General) QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/1/PharmacognJ-10-110.pdf http://irep.iium.edu.my/60005/7/60005_GC-MS%20analysis%20of%20phytochemical%20compounds_scopus.pdf

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spelling	iium-600052018-08-12T13:34:55Z http://irep.iium.edu.my/60005/ GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method Abd Rahim, Erlena Nor Asmira Ismail, Azlini Omar, Muhammad Nor Rahmat, Umi Nadhirah Wan Ahmad, Wan Amir Nizam Q Science (General) QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Context: Syzygium polyanthum has been traditionally formulated by the folklore for the treatment of diseases including diarrhea, rheumatism, diabetes mellitus, hypercholesterolemia, hypertension, gastritis and hyperuricemia. Normally, its phytochemicals are always extracted using solvent, maceration and steam distillation methods, but the use of ultrasound-assisted extraction (UAE) method is still not well documented. Aims: This study aims to extract the phytochemical compounds present in S. polyanthum leaves using UAE and to identify them by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Methodology: The leaves were consecutively soaked with n-hexane, ethyl acetate and methanol in a bath sonicator to derive n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) extracts of S. polyanthum leaves and then the extracts were subjected to GC-MS analysis. Mass-spectral databases of peaks were compared with database from Wiley, NIST and FNSCC libraries for compound identification. Results: GC-MS analyses of HSP, EASP and MSP showed the presence of 21, 27, and 31 peaks, respectively. The major compound for HSP (31.912%), EASP (27.042%), and MSP (22.386%) were unknown compounds which were detected at retention time between 61.980 and 62.29 min, thus requires further characterization. Squalene and phytol were among the other major compounds present in all three extracts. Several identified compounds in the extracts such as squalene, phytol, hentriacontane, palmitic acid, α-pinene, nerolidol, linalool, α-tocopherol and β-tocopherol were known bioactive compounds. Conclusion: GC-MS analyses of n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) of S. polyanthum leaves extracts have revealed the presence of some known bioactive compounds with therapeutic importance. Pharmacognosy Network Worldwide 2018-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60005/1/PharmacognJ-10-110.pdf application/pdf en http://irep.iium.edu.my/60005/7/60005_GC-MS%20analysis%20of%20phytochemical%20compounds_scopus.pdf Abd Rahim, Erlena Nor Asmira and Ismail, Azlini and Omar, Muhammad Nor and Rahmat, Umi Nadhirah and Wan Ahmad, Wan Amir Nizam (2018) GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method. Pharmacognosy Journal, 10 (1). pp. 110-119. ISSN 0975-3575 http://www.phcogj.com/sites/default/files/PharmacognJ-10-110.pdf 10.5530/pj.2018.1.20
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	Q Science (General) QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Abd Rahim, Erlena Nor Asmira Ismail, Azlini Omar, Muhammad Nor Rahmat, Umi Nadhirah Wan Ahmad, Wan Amir Nizam GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
description	Context: Syzygium polyanthum has been traditionally formulated by the folklore for the treatment of diseases including diarrhea, rheumatism, diabetes mellitus, hypercholesterolemia, hypertension, gastritis and hyperuricemia. Normally, its phytochemicals are always extracted using solvent, maceration and steam distillation methods, but the use of ultrasound-assisted extraction (UAE) method is still not well documented. Aims: This study aims to extract the phytochemical compounds present in S. polyanthum leaves using UAE and to identify them by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Methodology: The leaves were consecutively soaked with n-hexane, ethyl acetate and methanol in a bath sonicator to derive n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) extracts of S. polyanthum leaves and then the extracts were subjected to GC-MS analysis. Mass-spectral databases of peaks were compared with database from Wiley, NIST and FNSCC libraries for compound identification. Results: GC-MS analyses of HSP, EASP and MSP showed the presence of 21, 27, and 31 peaks, respectively. The major compound for HSP (31.912%), EASP (27.042%), and MSP (22.386%) were unknown compounds which were detected at retention time between 61.980 and 62.29 min, thus requires further characterization. Squalene and phytol were among the other major compounds present in all three extracts. Several identified compounds in the extracts such as squalene, phytol, hentriacontane, palmitic acid, α-pinene, nerolidol, linalool, α-tocopherol and β-tocopherol were known bioactive compounds. Conclusion: GC-MS analyses of n-hexane (HSP), ethyl acetate (EASP), and methanol (MSP) of S. polyanthum leaves extracts have revealed the presence of some known bioactive compounds with therapeutic importance.
format	Article
author	Abd Rahim, Erlena Nor Asmira Ismail, Azlini Omar, Muhammad Nor Rahmat, Umi Nadhirah Wan Ahmad, Wan Amir Nizam
author_facet	Abd Rahim, Erlena Nor Asmira Ismail, Azlini Omar, Muhammad Nor Rahmat, Umi Nadhirah Wan Ahmad, Wan Amir Nizam
author_sort	Abd Rahim, Erlena Nor Asmira
title	GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
title_short	GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
title_full	GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
title_fullStr	GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
title_full_unstemmed	GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
title_sort	gc-ms analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method
publisher	Pharmacognosy Network Worldwide
publishDate	2018
url	http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/ http://irep.iium.edu.my/60005/1/PharmacognJ-10-110.pdf http://irep.iium.edu.my/60005/7/60005_GC-MS%20analysis%20of%20phytochemical%20compounds_scopus.pdf
first_indexed	2023-09-18T21:25:03Z
last_indexed	2023-09-18T21:25:03Z
_version_	1777412135765147648

GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method

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