P-TEFb goes viral

Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive elongation of transcription of...

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Main Authors:	Zaborowska, Justyna, Isa, Nur Firdaus, Murphy, Shona
Format:	Article
Language:	English English
Published:	John Wiley and Sons Inc. 2016
Subjects:	Q Science (General) R Medicine (General)
Online Access:	http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/1/2015-P-TEFb%20goes%20viral.pdf http://irep.iium.edu.my/60287/7/60287_P-TEFb%20goes%20viral_scopus.pdf

id	iium-60287
recordtype	eprints
spelling	iium-602872017-12-26T09:16:22Z http://irep.iium.edu.my/60287/ P-TEFb goes viral Zaborowska, Justyna Isa, Nur Firdaus Murphy, Shona Q Science (General) R Medicine (General) Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive elongation of transcription of protein-coding genes by RNA polymerase II (pol II). In addition, P-TEFbmediated phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of pol II mediates the recruitment of transcription and RNA processing factors during the transcription cycle. CDK9 also phosphorylates p53, a tumor suppressor that plays a central role in cellular responses to a range of stress factors. Many viral factors affect transcription by recruiting or modulating the activity of CDK9. In this review, we will focus on how the function of CDK9 is regulated by viral gene products. The central role of CDK9 in viral life cycles suggests that drugs targeting the interaction between viral products and P-TEFb could be effective anti-viral agents. John Wiley and Sons Inc. 2016-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60287/1/2015-P-TEFb%20goes%20viral.pdf application/pdf en http://irep.iium.edu.my/60287/7/60287_P-TEFb%20goes%20viral_scopus.pdf Zaborowska, Justyna and Isa, Nur Firdaus and Murphy, Shona (2016) P-TEFb goes viral. Bioessays, 38. S75-S85. ISSN 0265-9247 E-ISSN 1521-1878 http://onlinelibrary.wiley.com/doi/10.1002/icl3.1037/epdf 10.1002/bies.201670912
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) R Medicine (General)
spellingShingle	Q Science (General) R Medicine (General) Zaborowska, Justyna Isa, Nur Firdaus Murphy, Shona P-TEFb goes viral
description	Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive elongation of transcription of protein-coding genes by RNA polymerase II (pol II). In addition, P-TEFbmediated phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of pol II mediates the recruitment of transcription and RNA processing factors during the transcription cycle. CDK9 also phosphorylates p53, a tumor suppressor that plays a central role in cellular responses to a range of stress factors. Many viral factors affect transcription by recruiting or modulating the activity of CDK9. In this review, we will focus on how the function of CDK9 is regulated by viral gene products. The central role of CDK9 in viral life cycles suggests that drugs targeting the interaction between viral products and P-TEFb could be effective anti-viral agents.
format	Article
author	Zaborowska, Justyna Isa, Nur Firdaus Murphy, Shona
author_facet	Zaborowska, Justyna Isa, Nur Firdaus Murphy, Shona
author_sort	Zaborowska, Justyna
title	P-TEFb goes viral
title_short	P-TEFb goes viral
title_full	P-TEFb goes viral
title_fullStr	P-TEFb goes viral
title_full_unstemmed	P-TEFb goes viral
title_sort	p-tefb goes viral
publisher	John Wiley and Sons Inc.
publishDate	2016
url	http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/ http://irep.iium.edu.my/60287/1/2015-P-TEFb%20goes%20viral.pdf http://irep.iium.edu.my/60287/7/60287_P-TEFb%20goes%20viral_scopus.pdf
first_indexed	2023-09-18T21:25:28Z
last_indexed	2023-09-18T21:25:28Z
_version_	1777412161662877696

P-TEFb goes viral

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