CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes
Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Nature Publishing Group
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/60432/ http://irep.iium.edu.my/60432/ http://irep.iium.edu.my/60432/ http://irep.iium.edu.my/60432/1/2015-NSMB.pdf http://irep.iium.edu.my/60432/7/60432_CDK9%20inhibitors%20define%20elongation_scopus.pdf |