Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate

Understanding of the nucleation events and metastable zone width are essential in the crystallization process. This study investigates the use of cheap process analytical technology tools namely conductivity in comparison with the turbidity system for in-line detection of polymorph nucleation event...

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Main Authors:	Abdul Mudalip, Siti Kholijah, Abu Bakar, Mohd Rushdi, Jamal, Parveen, Alam, Md. Zahangir, Adam, Fatmawati
Format:	Article
Language:	English English
Published:	Medwell Journals 2017
Subjects:	TP155 Chemical engineering
Online Access:	http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/1/Paper%20Kholija2.pdf http://irep.iium.edu.my/60629/7/60629-ucleation%20events%20and%20metastable%20zone-SCOPUS.pdf

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spelling	iium-606292018-01-02T03:00:14Z http://irep.iium.edu.my/60629/ Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Alam, Md. Zahangir Adam, Fatmawati TP155 Chemical engineering Understanding of the nucleation events and metastable zone width are essential in the crystallization process. This study investigates the use of cheap process analytical technology tools namely conductivity in comparison with the turbidity system for in-line detection of polymorph nucleation event in the solution crystallization. The effects of different cooling rates and initial concentrations on Metastable Zone Width (MSZW), nucleation kinetics and polymorphism of mefenamic acid in ethyl acetate solution were analyzed. The MSZW data and nucleation kinetics parameter were estimated based on the recorded nucleation temperatures. The recorded nucleation temperatures based on in-line conductivity data are in agreement with the in-line turbidity system. The MSZW was found to increase with the increase of cooling rates and decrease with the increase of saturation concentration. The nucleation order and nucleation rate constant kn calculated from MSZW data using Nyvlt classical theory varied with the initial solution concentration. The highest solution concentration which was 3.6/100 g ethyl acetate, shows highest (0.1460) and lowest n (4.1374) values. This indicates fast nucleation at higher solution concentration. The crystallization using different cooling rates does not show significant effect on the final polymorphs chemistry where mefenamic acid Form I was produced. Medwell Journals 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60629/1/Paper%20Kholija2.pdf application/pdf en http://irep.iium.edu.my/60629/7/60629-ucleation%20events%20and%20metastable%20zone-SCOPUS.pdf Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Alam, Md. Zahangir and Adam, Fatmawati (2017) Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate. Journal of Engineering and Applied Sciences, 12 (4). pp. 1031-1039. ISSN 1816-949X E-ISSN 1818-7803 http://medwelljournals.com/abstract/?doi=jeasci.2017.1031.1039 10.3923/jeasci.2017.1031.1039
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP155 Chemical engineering
spellingShingle	TP155 Chemical engineering Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Alam, Md. Zahangir Adam, Fatmawati Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
description	Understanding of the nucleation events and metastable zone width are essential in the crystallization process. This study investigates the use of cheap process analytical technology tools namely conductivity in comparison with the turbidity system for in-line detection of polymorph nucleation event in the solution crystallization. The effects of different cooling rates and initial concentrations on Metastable Zone Width (MSZW), nucleation kinetics and polymorphism of mefenamic acid in ethyl acetate solution were analyzed. The MSZW data and nucleation kinetics parameter were estimated based on the recorded nucleation temperatures. The recorded nucleation temperatures based on in-line conductivity data are in agreement with the in-line turbidity system. The MSZW was found to increase with the increase of cooling rates and decrease with the increase of saturation concentration. The nucleation order and nucleation rate constant kn calculated from MSZW data using Nyvlt classical theory varied with the initial solution concentration. The highest solution concentration which was 3.6/100 g ethyl acetate, shows highest (0.1460) and lowest n (4.1374) values. This indicates fast nucleation at higher solution concentration. The crystallization using different cooling rates does not show significant effect on the final polymorphs chemistry where mefenamic acid Form I was produced.
format	Article
author	Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Alam, Md. Zahangir Adam, Fatmawati
author_facet	Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Alam, Md. Zahangir Adam, Fatmawati
author_sort	Abdul Mudalip, Siti Kholijah
title	Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
title_short	Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
title_full	Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
title_fullStr	Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
title_full_unstemmed	Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
title_sort	nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate
publisher	Medwell Journals
publishDate	2017
url	http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/ http://irep.iium.edu.my/60629/1/Paper%20Kholija2.pdf http://irep.iium.edu.my/60629/7/60629-ucleation%20events%20and%20metastable%20zone-SCOPUS.pdf
first_indexed	2023-09-18T21:25:57Z
last_indexed	2023-09-18T21:25:57Z
_version_	1777412192511983616

Nucleation events and metastable zone width of mefenamic acid polymorph in ethyl acetate

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