Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls

Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AI...

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Main Authors:	Shalash, Ali, Salama, Mohamed, Makar, Marianne, Roushdy, Tamer, Elrassas, Hannan hany, Mohamed, Wael Mohamed Yousef, ElBalkimy, Mahmoud, Abu Donia, Mohamed
Format:	Article
Language:	English English
Published:	Frontiers Media S.A. 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf

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recordtype	eprints
spelling	iium-608032018-04-20T04:23:39Z http://irep.iium.edu.my/60803/ Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed R Medicine (General) Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD. Frontiers Media S.A. 2017-12-22 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf application/pdf en http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf Shalash, Ali and Salama, Mohamed and Makar, Marianne and Roushdy, Tamer and Elrassas, Hannan hany and Mohamed, Wael Mohamed Yousef and ElBalkimy, Mahmoud and Abu Donia, Mohamed (2017) Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls. Frontiers in Neurology, 8. pp. 1-6. ISSN 1664-2295 https://www.frontiersin.org/articles/10.3389/fneur.2017.00720/full 10.3389/fneur.2017.00720
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
description	Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD.
format	Article
author	Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed
author_facet	Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed
author_sort	Shalash, Ali
title	Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
title_short	Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
title_full	Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
title_fullStr	Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
title_full_unstemmed	Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
title_sort	elevated serum α-synuclein autoantibodies in patients with parkinson’s disease relative to alzheimer’s disease and controls
publisher	Frontiers Media S.A.
publishDate	2017
url	http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf
first_indexed	2023-09-18T21:26:11Z
last_indexed	2023-09-18T21:26:11Z
_version_	1777412207515009024

Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls

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