Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol

Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential a...

Full description

Bibliographic Details
Main Authors: Ridzuan, P. M., Mohamad, Nasir, Ismail, Salwani, A. Rahman, Nor Iza, Sanusi, N. A., Umar, Rabiatul Adawiyah, Hamzah, Hairul Aini, Buyong, Zunariah, Mohd Hassan, Norazian, Baharudin, Roesnita
Format: Article
Language:English
English
Published: International Islamic University Malaysia 2017
Subjects:
Online Access:http://irep.iium.edu.my/60896/
http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf
http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf
id iium-60896
recordtype eprints
spelling iium-608962018-01-12T11:24:05Z http://irep.iium.edu.my/60896/ Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita QR Microbiology Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections. International Islamic University Malaysia 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf application/pdf en http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and A. Rahman, Nor Iza and Sanusi, N. A. and Umar, Rabiatul Adawiyah and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2017) Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol. International Medical Journal Malaysia, 16 (2). pp. 65-71. ISSN 1823-4631 E-ISSN 1823-4631
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic QR Microbiology
spellingShingle QR Microbiology
Ridzuan, P. M.
Mohamad, Nasir
Ismail, Salwani
A. Rahman, Nor Iza
Sanusi, N. A.
Umar, Rabiatul Adawiyah
Hamzah, Hairul Aini
Buyong, Zunariah
Mohd Hassan, Norazian
Baharudin, Roesnita
Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
description Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections.
format Article
author Ridzuan, P. M.
Mohamad, Nasir
Ismail, Salwani
A. Rahman, Nor Iza
Sanusi, N. A.
Umar, Rabiatul Adawiyah
Hamzah, Hairul Aini
Buyong, Zunariah
Mohd Hassan, Norazian
Baharudin, Roesnita
author_facet Ridzuan, P. M.
Mohamad, Nasir
Ismail, Salwani
A. Rahman, Nor Iza
Sanusi, N. A.
Umar, Rabiatul Adawiyah
Hamzah, Hairul Aini
Buyong, Zunariah
Mohd Hassan, Norazian
Baharudin, Roesnita
author_sort Ridzuan, P. M.
title Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_short Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_full Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_fullStr Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_full_unstemmed Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_sort ultra-morphological changes of trichophyton rubrum treated with hydroxychavicol
publisher International Islamic University Malaysia
publishDate 2017
url http://irep.iium.edu.my/60896/
http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf
http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf
first_indexed 2023-09-18T21:26:21Z
last_indexed 2023-09-18T21:26:21Z
_version_ 1777412217263620096