Rheological characterization of different gelling polymers for dental gel formulation

Objective: This study is aimed to select the best gelling agents as candidates to be developed into dental gels, based on their rheological profiles. Significance: This study opens up more options for dental gel formulator to choose regarding the range of good gelling polymers, as the vehicle for...

Full description

Bibliographic Details
Main Authors:	Abdul Rahman, Mohammad Nasrin, Abdul Qader, Omar Abdul Jabbar, Sukmasari, Susi, Ismail, Ahmad Faisal, Doolaanea, Abd Almonem
Format:	Article
Language:	English English
Published:	PharmaInfo Publications 2017
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/1/Abdul%20Rahman%20et%20al%202017.pdf http://irep.iium.edu.my/61333/7/61333_Rheological%20characterization%20of%20different_scopus.pdf

id	iium-61333
recordtype	eprints
spelling	iium-613332018-03-25T09:15:34Z http://irep.iium.edu.my/61333/ Rheological characterization of different gelling polymers for dental gel formulation Abdul Rahman, Mohammad Nasrin Abdul Qader, Omar Abdul Jabbar Sukmasari, Susi Ismail, Ahmad Faisal Doolaanea, Abd Almonem RM Therapeutics. Pharmacology RS Pharmacy and materia medica Objective: This study is aimed to select the best gelling agents as candidates to be developed into dental gels, based on their rheological profiles. Significance: This study opens up more options for dental gel formulator to choose regarding the range of good gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: 11 types of gelling agents, which consist of 1%, 3%, and 5% w/w concentration for each gel, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to calculate their apparent viscosities, rheological modelling, and the linear viscoelastic range profiles. Results: It was found that 3%, 5% carbopol 940, 5% guar gum, 5% ι-carrageenan 3% kelcogel F, 1%, 3%, and 5% w/w konjac gum are the best candidates to be developed into dental gels based on their rheological properties. They exhibit good viscoelastic properties, acceptable viscosity profiles at three different shear rates of 10 s-1, 50 s-1, and 100 s-1 Pas, having high consistency factor (K), best flow behaviour (n) value, high G’ value, G’=G” value, and the crossing point of G’ and G” happens at further shear stress range compared to other gels. Conclusion: All the rheological profiles for each of the gels at 3 different concentrations were successfully characterized, analyzed and documented. PharmaInfo Publications 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61333/1/Abdul%20Rahman%20et%20al%202017.pdf application/pdf en http://irep.iium.edu.my/61333/7/61333_Rheological%20characterization%20of%20different_scopus.pdf Abdul Rahman, Mohammad Nasrin and Abdul Qader, Omar Abdul Jabbar and Sukmasari, Susi and Ismail, Ahmad Faisal and Doolaanea, Abd Almonem (2017) Rheological characterization of different gelling polymers for dental gel formulation. Journal of Pharmaceutical Sciences and Research, 9 (12). pp. 2633-2640. ISSN 0975-1459 http://www.jpsr.pharmainfo.in/Documents/Volumes/vol9Issue12/jpsr09121768.pdf www.jpsr.pharmainfo.in/Documents/Volumes/vol9Issue12/jpsr09121768.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul Rahman, Mohammad Nasrin Abdul Qader, Omar Abdul Jabbar Sukmasari, Susi Ismail, Ahmad Faisal Doolaanea, Abd Almonem Rheological characterization of different gelling polymers for dental gel formulation
description	Objective: This study is aimed to select the best gelling agents as candidates to be developed into dental gels, based on their rheological profiles. Significance: This study opens up more options for dental gel formulator to choose regarding the range of good gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: 11 types of gelling agents, which consist of 1%, 3%, and 5% w/w concentration for each gel, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to calculate their apparent viscosities, rheological modelling, and the linear viscoelastic range profiles. Results: It was found that 3%, 5% carbopol 940, 5% guar gum, 5% ι-carrageenan 3% kelcogel F, 1%, 3%, and 5% w/w konjac gum are the best candidates to be developed into dental gels based on their rheological properties. They exhibit good viscoelastic properties, acceptable viscosity profiles at three different shear rates of 10 s-1, 50 s-1, and 100 s-1 Pas, having high consistency factor (K), best flow behaviour (n) value, high G’ value, G’=G” value, and the crossing point of G’ and G” happens at further shear stress range compared to other gels. Conclusion: All the rheological profiles for each of the gels at 3 different concentrations were successfully characterized, analyzed and documented.
format	Article
author	Abdul Rahman, Mohammad Nasrin Abdul Qader, Omar Abdul Jabbar Sukmasari, Susi Ismail, Ahmad Faisal Doolaanea, Abd Almonem
author_facet	Abdul Rahman, Mohammad Nasrin Abdul Qader, Omar Abdul Jabbar Sukmasari, Susi Ismail, Ahmad Faisal Doolaanea, Abd Almonem
author_sort	Abdul Rahman, Mohammad Nasrin
title	Rheological characterization of different gelling polymers for dental gel formulation
title_short	Rheological characterization of different gelling polymers for dental gel formulation
title_full	Rheological characterization of different gelling polymers for dental gel formulation
title_fullStr	Rheological characterization of different gelling polymers for dental gel formulation
title_full_unstemmed	Rheological characterization of different gelling polymers for dental gel formulation
title_sort	rheological characterization of different gelling polymers for dental gel formulation
publisher	PharmaInfo Publications
publishDate	2017
url	http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/ http://irep.iium.edu.my/61333/1/Abdul%20Rahman%20et%20al%202017.pdf http://irep.iium.edu.my/61333/7/61333_Rheological%20characterization%20of%20different_scopus.pdf
first_indexed	2023-09-18T21:26:59Z
last_indexed	2023-09-18T21:26:59Z
_version_	1777412257787936768

Rheological characterization of different gelling polymers for dental gel formulation

Similar Items