The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation

The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fi...

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Main Authors:	Balakrishnan, Theenesh, Zulkifly, Ahmad Hafiz, Mohd Jan, Nurul Hafiza, Ibrahim, Mohd Zulfadzli, Sha'ban, Munirah, Md Nazir, Noorhidayah
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/61436/ http://irep.iium.edu.my/61436/ http://irep.iium.edu.my/61436/17/61436-The%20In-vivo%20Study%20Comparison%20of%20Biocompatibility%20and%20Biodegradability.pdf

id	iium-61436
recordtype	eprints
spelling	iium-614362018-01-17T03:07:07Z http://irep.iium.edu.my/61436/ The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Md Nazir, Noorhidayah RD701 Orthopedics The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fibrin. The objective of this study is to compare biocompatibility and biodegradability of polymer (PLGA combined with fibrin) with PLGA for intra-articular screw fixation through micro-CT scan evaluation. We used fabricated PLGA scaffolds in combination with autologous fibrin for an in-vivo prospective research. A total of 9 New Zealand White Rabbits (NZWR) were operated and the scaffolds were implanted at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6, 12 and 24 weeks (3 NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. The combination of PLGA and fibrin have better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Biodegradable polymer PLGA with incorporation of fibrin results in superior outcome compared to usage of other current biodegradable polymers. 2017-11-07 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/61436/17/61436-The%20In-vivo%20Study%20Comparison%20of%20Biocompatibility%20and%20Biodegradability.pdf Balakrishnan, Theenesh and Zulkifly, Ahmad Hafiz and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah and Md Nazir, Noorhidayah (2017) The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation. In: 1st Postgraduate Symposium on Tissue Engineering and Regenerative Medicine 2017 (TERMSYMPO 2017), 7th November 2017, Cheras, Kuala Lumpur. (Unpublished) https://termsympo2017.files.wordpress.com/2017/08/abstract-book.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Md Nazir, Noorhidayah The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
description	The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fibrin. The objective of this study is to compare biocompatibility and biodegradability of polymer (PLGA combined with fibrin) with PLGA for intra-articular screw fixation through micro-CT scan evaluation. We used fabricated PLGA scaffolds in combination with autologous fibrin for an in-vivo prospective research. A total of 9 New Zealand White Rabbits (NZWR) were operated and the scaffolds were implanted at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6, 12 and 24 weeks (3 NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. The combination of PLGA and fibrin have better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Biodegradable polymer PLGA with incorporation of fibrin results in superior outcome compared to usage of other current biodegradable polymers.
format	Conference or Workshop Item
author	Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Md Nazir, Noorhidayah
author_facet	Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Md Nazir, Noorhidayah
author_sort	Balakrishnan, Theenesh
title	The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
title_short	The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
title_full	The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
title_fullStr	The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
title_full_unstemmed	The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation
title_sort	in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra-articular screw fixation in new zealand white rabbits model - the micro-ct scan evaluation
publishDate	2017
url	http://irep.iium.edu.my/61436/ http://irep.iium.edu.my/61436/ http://irep.iium.edu.my/61436/17/61436-The%20In-vivo%20Study%20Comparison%20of%20Biocompatibility%20and%20Biodegradability.pdf
first_indexed	2023-09-18T21:27:08Z
last_indexed	2023-09-18T21:27:08Z
_version_	1777412267044765696

The in-vivo study comparison of biocompatibility and biodegradability of poly lactic-co-glycolic acid (PLGA) combined with autologous fibrin versus PLGA for intra-articular screw fixation in New Zealand white rabbits model - The micro-CT scan evaluation

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