The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection

The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overc...

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Main Authors:	Mohd Jan, Nurul Hafiza, Zulkifly, Ahmad Hafiz, Ibrahim, Mohd Zulfadzli, Sha'ban, Munirah, Mohd Toff, Mohd Radzi
Format:	Conference or Workshop Item
Language:	English English English English
Published:	Elsevier 2019
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf

id	iium-61449
recordtype	eprints
spelling	iium-614492019-10-11T01:04:25Z http://irep.iium.edu.my/61449/ The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi RD701 Orthopedics The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overcome by application of orthopaedic metallic implant coated with silver composite (OMICS) as alternative treatment of implant-infection related. The aimed of these studies were to evaluate the potential effect of orthopedic metal implant (plate) coated with silver composite through in vitro and in vivo experimental settings. Antimicrobial test through in vitro analysis indicated that OMICS showed excellent response of antibacterial agent against Staphylococcus aureus. The effects of OMICS on open fracture related with infection were assessed in New Zealand White Rabbit models. All rabbits were implanted with OMICS after six hours of tibial bone exposure. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. These studies indicated that silver has antibacterial properties. In conclusion, these values suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections. Elsevier 2019 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf application/pdf en http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf application/pdf en http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf application/pdf en http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah and Mohd Toff, Mohd Radzi (2019) The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection. In: Bio-CAM 2017 Conference on Biomedical & Advanced Material, 28th-29th November 2017, Langkawi, Kedah. https://www.sciencedirect.com/science/article/pii/S2214785319314336 10.1016/j.matpr.2019.06.084
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
description	The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overcome by application of orthopaedic metallic implant coated with silver composite (OMICS) as alternative treatment of implant-infection related. The aimed of these studies were to evaluate the potential effect of orthopedic metal implant (plate) coated with silver composite through in vitro and in vivo experimental settings. Antimicrobial test through in vitro analysis indicated that OMICS showed excellent response of antibacterial agent against Staphylococcus aureus. The effects of OMICS on open fracture related with infection were assessed in New Zealand White Rabbit models. All rabbits were implanted with OMICS after six hours of tibial bone exposure. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. These studies indicated that silver has antibacterial properties. In conclusion, these values suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections.
format	Conference or Workshop Item
author	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi
author_facet	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi
author_sort	Mohd Jan, Nurul Hafiza
title	The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
title_short	The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
title_full	The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
title_fullStr	The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
title_full_unstemmed	The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
title_sort	in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: potential treatment modality for implant related infection
publisher	Elsevier
publishDate	2019
url	http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf
first_indexed	2023-09-18T21:27:09Z
last_indexed	2023-09-18T21:27:09Z
_version_	1777412268078661632

The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection

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