The evaluation of physicochemical and anti-microbial properties of honey based hydrogel

NTRODUCTION: Hydrogel possess a three-dimensional cross linked networks of hydrophilic polymers. Honey contain anti-microbial properties due to its peroxide and non-peroxide components.OBJECTIVES: To develop and characterize honey based hydrogel formulation and to evaluate its anti-microbial propert...

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Main Authors:	Abdul Jalil, Mohd Azri, Kasmuri, Abdul Razak, Ab. Hadi, Hazrina
Format:	Article
Language:	English English
Published:	Malaysian Pharmaceutical Society 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/61756/ http://irep.iium.edu.my/61756/ http://irep.iium.edu.my/61756/19/61756-The%20Evaluation%20of%20Physicochemical.pdf http://irep.iium.edu.my/61756/3/MPS_Mohd%20Azri%20Abd%20Jalil.pdf

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spelling	iium-617562018-02-06T05:03:40Z http://irep.iium.edu.my/61756/ The evaluation of physicochemical and anti-microbial properties of honey based hydrogel Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak Ab. Hadi, Hazrina RS Pharmacy and materia medica NTRODUCTION: Hydrogel possess a three-dimensional cross linked networks of hydrophilic polymers. Honey contain anti-microbial properties due to its peroxide and non-peroxide components.OBJECTIVES: To develop and characterize honey based hydrogel formulation and to evaluate its anti-microbial properties. METHODS: The hydrogel were developed by combining polyvinyl alcohol (PVA) and polyethylene glycol (PEG). 1% protein-free agar was added to the combination as well as honey according to their respective formulations. Then, the characterization tests consist of gel fraction, swelling ratio and water vapour transmission (WVTR) were conducted. For the antimicrobial evaluation, microbial limit test and agar diffusion test were conducted against Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS: For the gel fraction test, the control formulation was significantly (p<0.05) highest among the others; indicates that the PVA in this formulation was almost completely cross-linked. For the swelling ratio test, formulation 2 that contain 20% (w/v) honey was significantly (p<0.05) higher than the control and agar groups; indicates a higher water uptake occurred. The WVTR of formulation 2 was within the recommended range which is in between 80–105gm -2day -1. Formulation 5 with 40% (w/v) honey has shown anti-microbial effect towards Staphylococcus aureus. For microbial limit tests, all formulations showed the absence of bacteria in their respective surfaces.CONCLUSIONS: Formulation 2 demonstrated significantly better physicochemical properties but displaying no anti-microbial properties. However, formulation 5 showed an acceptable physicochemical properties but able to display a good anti-microbial properties. Therefore, formulation 5 will be selected for further studies. Keywords: hydrogel, honey, anti-microbial Malaysian Pharmaceutical Society 2017-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61756/19/61756-The%20Evaluation%20of%20Physicochemical.pdf application/pdf en http://irep.iium.edu.my/61756/3/MPS_Mohd%20Azri%20Abd%20Jalil.pdf Abdul Jalil, Mohd Azri and Kasmuri, Abdul Razak and Ab. Hadi, Hazrina (2017) The evaluation of physicochemical and anti-microbial properties of honey based hydrogel. Malaysian Journal of Pharmacy, 3 (1 (Supplement)). p. 25. ISSN 1675-3666 http://www.mps.org.my/index.cfm?&menuid=146
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak Ab. Hadi, Hazrina The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
description	NTRODUCTION: Hydrogel possess a three-dimensional cross linked networks of hydrophilic polymers. Honey contain anti-microbial properties due to its peroxide and non-peroxide components.OBJECTIVES: To develop and characterize honey based hydrogel formulation and to evaluate its anti-microbial properties. METHODS: The hydrogel were developed by combining polyvinyl alcohol (PVA) and polyethylene glycol (PEG). 1% protein-free agar was added to the combination as well as honey according to their respective formulations. Then, the characterization tests consist of gel fraction, swelling ratio and water vapour transmission (WVTR) were conducted. For the antimicrobial evaluation, microbial limit test and agar diffusion test were conducted against Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS: For the gel fraction test, the control formulation was significantly (p<0.05) highest among the others; indicates that the PVA in this formulation was almost completely cross-linked. For the swelling ratio test, formulation 2 that contain 20% (w/v) honey was significantly (p<0.05) higher than the control and agar groups; indicates a higher water uptake occurred. The WVTR of formulation 2 was within the recommended range which is in between 80–105gm -2day -1. Formulation 5 with 40% (w/v) honey has shown anti-microbial effect towards Staphylococcus aureus. For microbial limit tests, all formulations showed the absence of bacteria in their respective surfaces.CONCLUSIONS: Formulation 2 demonstrated significantly better physicochemical properties but displaying no anti-microbial properties. However, formulation 5 showed an acceptable physicochemical properties but able to display a good anti-microbial properties. Therefore, formulation 5 will be selected for further studies. Keywords: hydrogel, honey, anti-microbial
format	Article
author	Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak Ab. Hadi, Hazrina
author_facet	Abdul Jalil, Mohd Azri Kasmuri, Abdul Razak Ab. Hadi, Hazrina
author_sort	Abdul Jalil, Mohd Azri
title	The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
title_short	The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
title_full	The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
title_fullStr	The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
title_full_unstemmed	The evaluation of physicochemical and anti-microbial properties of honey based hydrogel
title_sort	evaluation of physicochemical and anti-microbial properties of honey based hydrogel
publisher	Malaysian Pharmaceutical Society
publishDate	2017
url	http://irep.iium.edu.my/61756/ http://irep.iium.edu.my/61756/ http://irep.iium.edu.my/61756/19/61756-The%20Evaluation%20of%20Physicochemical.pdf http://irep.iium.edu.my/61756/3/MPS_Mohd%20Azri%20Abd%20Jalil.pdf
first_indexed	2023-09-18T21:27:34Z
last_indexed	2023-09-18T21:27:34Z
_version_	1777412294475513856

The evaluation of physicochemical and anti-microbial properties of honey based hydrogel

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