The release profiles of Baccaurea angulata extract from various gelling agents
This study investigates the release profiles of Baccaurea angulata extracts incorporated in carbopol, guar gum, and konjac gum. Franz cell diffusion was run for 24h for finite dosing, and 6h for infinite dosing. From finite dosing, carbopol had the highest cumulative amount permeated, (75.75±1.18% c...
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PharmaInfo Publications
2018
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| Online Access: | http://irep.iium.edu.my/61772/ http://irep.iium.edu.my/61772/ http://irep.iium.edu.my/61772/1/61772_The%20Release%20Profiles.pdf http://irep.iium.edu.my/61772/7/61772_The%20Release%20Profiles_scopus.pdf |
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iium-617722018-08-10T08:32:38Z http://irep.iium.edu.my/61772/ The release profiles of Baccaurea angulata extract from various gelling agents Sukmasari, Susi Abdul Qader, Omar Abdul Jabbar Abdul Rahman, Mohammad Nasrin Ibrahim, Muhammad Doolaanea, Abd Almonem RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RS192 Materia Medica-Pharmaceutical Technology This study investigates the release profiles of Baccaurea angulata extracts incorporated in carbopol, guar gum, and konjac gum. Franz cell diffusion was run for 24h for finite dosing, and 6h for infinite dosing. From finite dosing, carbopol had the highest cumulative amount permeated, (75.75±1.18% content release) compared to guar gum and konjac gum (p<0.05). Carbopol exhibited the fastest release profile with the highest mean flux (29.04±0.74μg/cm2/h) (p<0.05) permeated within the first 0.75h. Konjac gum had faster release behavior compared to guar gum. However, the amount of content release by guar gum was higher compared to konjac gum for the total of 24h (p<0.05). For infinite dosing, the cumulative amount of content released by carbopol was the highest (4095.97±38.70μg) compared to guar gum and konjac gum (p < 0.05). Steady state flux of carbopol was the highest (379.26±3.58 μg/cm2/h) compared to guar gum and konjac gum (p<0.05). Carbopol showed the highest permeability coefficient: 6.20×10-2cm/h compared to guar gum and konjac gum (p<0.05). Guar gum had higher values in all calculated elements compared to konjac gum, except that its content release was slower. Therefore, it is concluded that carbopol has the best release profile to be developed as Baccaurea angulata dental gel. PharmaInfo Publications 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61772/1/61772_The%20Release%20Profiles.pdf application/pdf en http://irep.iium.edu.my/61772/7/61772_The%20Release%20Profiles_scopus.pdf Sukmasari, Susi and Abdul Qader, Omar Abdul Jabbar and Abdul Rahman, Mohammad Nasrin and Ibrahim, Muhammad and Doolaanea, Abd Almonem (2018) The release profiles of Baccaurea angulata extract from various gelling agents. Journal of Pharmaceutical Sciences and Research, 10 (1). pp. 45-50. ISSN 0975-1459 http://www.jpsr.pharmainfo.in/Documents/Volumes/vol10Issue01/jpsr10011809.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RS192 Materia Medica-Pharmaceutical Technology |
| spellingShingle |
RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works RS192 Materia Medica-Pharmaceutical Technology Sukmasari, Susi Abdul Qader, Omar Abdul Jabbar Abdul Rahman, Mohammad Nasrin Ibrahim, Muhammad Doolaanea, Abd Almonem The release profiles of Baccaurea angulata extract from various gelling agents |
| description |
This study investigates the release profiles of Baccaurea angulata extracts incorporated in carbopol, guar gum, and konjac gum. Franz cell diffusion was run for 24h for finite dosing, and 6h for infinite dosing. From finite dosing, carbopol had the highest cumulative amount permeated, (75.75±1.18% content release) compared to guar gum and konjac gum (p<0.05). Carbopol exhibited the fastest release profile with the highest mean flux (29.04±0.74μg/cm2/h) (p<0.05) permeated within the first 0.75h. Konjac gum had faster release behavior compared to guar gum. However, the amount of content release by guar gum was higher compared to konjac gum for the total of 24h (p<0.05). For infinite dosing, the cumulative amount of content released by carbopol was the highest (4095.97±38.70μg) compared to guar gum and konjac gum (p < 0.05). Steady state flux of carbopol was the highest (379.26±3.58 μg/cm2/h) compared to guar gum and konjac gum (p<0.05). Carbopol showed the highest permeability coefficient: 6.20×10-2cm/h compared to guar gum and konjac gum (p<0.05). Guar gum had higher values in all calculated elements compared to konjac gum, except that its content release was slower. Therefore, it is concluded that carbopol has the best release profile to be developed as Baccaurea angulata dental gel. |
| format |
Article |
| author |
Sukmasari, Susi Abdul Qader, Omar Abdul Jabbar Abdul Rahman, Mohammad Nasrin Ibrahim, Muhammad Doolaanea, Abd Almonem |
| author_facet |
Sukmasari, Susi Abdul Qader, Omar Abdul Jabbar Abdul Rahman, Mohammad Nasrin Ibrahim, Muhammad Doolaanea, Abd Almonem |
| author_sort |
Sukmasari, Susi |
| title |
The release profiles of Baccaurea angulata extract from various gelling agents |
| title_short |
The release profiles of Baccaurea angulata extract from various gelling agents |
| title_full |
The release profiles of Baccaurea angulata extract from various gelling agents |
| title_fullStr |
The release profiles of Baccaurea angulata extract from various gelling agents |
| title_full_unstemmed |
The release profiles of Baccaurea angulata extract from various gelling agents |
| title_sort |
release profiles of baccaurea angulata extract from various gelling agents |
| publisher |
PharmaInfo Publications |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/61772/ http://irep.iium.edu.my/61772/ http://irep.iium.edu.my/61772/1/61772_The%20Release%20Profiles.pdf http://irep.iium.edu.my/61772/7/61772_The%20Release%20Profiles_scopus.pdf |
| first_indexed |
2023-09-18T21:27:36Z |
| last_indexed |
2023-09-18T21:27:36Z |
| _version_ |
1777412295817691136 |