Understanding the significance variables for fabrication of fish gelatin nanoparticles by Plackett-Burman design
The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta p...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
IOP Publishing
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/61900/ http://irep.iium.edu.my/61900/ http://irep.iium.edu.my/61900/ http://irep.iium.edu.my/61900/1/FGNP_2018_IOP_Conf._Ser._Mater._Sci._Eng._290_012006.pdf http://irep.iium.edu.my/61900/7/61900_Understanding%20the%20significance%20variables%20for%20fabrication_scopus.pdf |
| Summary: | The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles
size, size distribution, and zeta potential were found in the range 240±9.76 nm, 0.3, and −9 mV, respectively. Statistical results explained that concentration of acetone, pH of solution during precipitation step and volume of cross linker had a most significant effect on particles size of fish gelatin nanoparticles. It was found that, time and chemical consuming is lower than previous research. This study revealed the potential of quality-by design in understanding the effects of process variables on the fish gelatin nanoparticles production. |
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