Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2
Transforming Growth Factor (TGF) β is a pleiotropic growth factor implicated in the development of atherosclerosis for its role in mediating glycosaminoglycan (GAG) chain hyperelongation on the proteoglycan biglycan, a phenomenon that leads to increased binding of atherogenic lipoproteins in the wal...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
American Society for Pharmacology and Experimental Therapeutics
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62174/ http://irep.iium.edu.my/62174/ http://irep.iium.edu.my/62174/ http://irep.iium.edu.my/62174/7/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_article.pdf http://irep.iium.edu.my/62174/8/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_scopus.pdf |