Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting

In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The pro...

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Main Authors:	Shazri, Syireen, Idres, Moumen
Format:	Conference or Workshop Item
Language:	English English
Published:	Institute of Physics Publishing 2017
Subjects:	T Technology (General)
Online Access:	http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf

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recordtype	eprints
spelling	iium-622882018-06-26T05:49:12Z http://irep.iium.edu.my/62288/ Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting Shazri, Syireen Idres, Moumen T Technology (General) In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The problem is divided into two steps; blood flow solution and nanoparticles trajectory solution. The blood flow in microvessel is obtained both analytically and numerically. Integration of nanoparticles equations of motion to obtain the trajectories is performed using both Matlab and ANSYS Fluent. Discrete Phase Model (DPM) in ANSYS Fluent is used for nanoparticles tracking. The dominant magnetization and drag forces acting on magnetic particles are incorporated to study the trajectories of magnetic particles. Parametric studies for steady flow with single point and multiple point injections are conducted. This includes varying particle diameter and magnet location. Critical minimum diameter for capturing is predicted. Capturing efficiency is reported for all cases. It is found that particle trajectories are strongly dependent on particle size and location of the magnet. The simulation can be used to determine the optimum particle size for treating a tumor, given its size and location. Institute of Physics Publishing 2017-04-03 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf application/pdf en http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf Shazri, Syireen and Idres, Moumen (2017) Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting. In: 3rd International Conference on Mechanical, Automotive and Aerospace Engineering 2016 (ICMAAE’16), 25th-27th July 2016, Kuala Lumpur, Malaysia. http://iopscience.iop.org/article/10.1088/1757-899X/184/1/012061/pdf 10.1088/1757-899X/184/1/012061
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	T Technology (General)
spellingShingle	T Technology (General) Shazri, Syireen Idres, Moumen Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
description	In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The problem is divided into two steps; blood flow solution and nanoparticles trajectory solution. The blood flow in microvessel is obtained both analytically and numerically. Integration of nanoparticles equations of motion to obtain the trajectories is performed using both Matlab and ANSYS Fluent. Discrete Phase Model (DPM) in ANSYS Fluent is used for nanoparticles tracking. The dominant magnetization and drag forces acting on magnetic particles are incorporated to study the trajectories of magnetic particles. Parametric studies for steady flow with single point and multiple point injections are conducted. This includes varying particle diameter and magnet location. Critical minimum diameter for capturing is predicted. Capturing efficiency is reported for all cases. It is found that particle trajectories are strongly dependent on particle size and location of the magnet. The simulation can be used to determine the optimum particle size for treating a tumor, given its size and location.
format	Conference or Workshop Item
author	Shazri, Syireen Idres, Moumen
author_facet	Shazri, Syireen Idres, Moumen
author_sort	Shazri, Syireen
title	Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_short	Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_full	Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_fullStr	Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_full_unstemmed	Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_sort	numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
publisher	Institute of Physics Publishing
publishDate	2017
url	http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/ http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf
first_indexed	2023-09-18T21:28:18Z
last_indexed	2023-09-18T21:28:18Z
_version_	1777412340349665280

Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting

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