A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were e...

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Main Authors:	Alhassan, Alhassan Muhammad, Ahmed, Qamar Uddin, Latip, Jalifah, Shah, Syed Adnan Ali
Format:	Article
Language:	English English English English
Published:	Taylor and Francis 2019
Subjects:	QE Geology
Online Access:	http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf

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spelling	iium-625152019-06-14T08:23:39Z http://irep.iium.edu.my/62515/ A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali QE Geology The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential. Taylor and Francis 2019-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf application/pdf en http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf application/pdf en http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf Alhassan, Alhassan Muhammad and Ahmed, Qamar Uddin and Latip, Jalifah and Shah, Syed Adnan Ali (2019) A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity. Natural Product Research, 33 (1). pp. 1-8. ISSN 1478-6427 (In Press) https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1437427?journalCode=gnpl20 10.1080/14786419.2018.1437427
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	QE Geology
spellingShingle	QE Geology Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
description	The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential.
format	Article
author	Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali
author_facet	Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali
author_sort	Alhassan, Alhassan Muhammad
title	A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_short	A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_full	A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_fullStr	A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_full_unstemmed	A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
title_sort	new sulphated flavone and other phytoconstituents from the leaves of tetracera indica merr. and their alpha-glucosidase inhibitory activity
publisher	Taylor and Francis
publishDate	2019
url	http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf
first_indexed	2023-09-18T21:28:35Z
last_indexed	2023-09-18T21:28:35Z
_version_	1777412358423969792

A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

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