Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community

Purpose: To compare the prevalence and type of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) on admission and discharge of patients, and to determine the associated predictors. Methods: This was a prospective observational study conducted in the multidiscip...

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Main Authors:	Akkawi, Muhammad Eid, Nik Mohamed, Mohamad Haniki
Format:	Article
Language:	English English English
Published:	University of Benin 2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/1/62641_Influence%20of%20hospitalization%20on%20potentially.pdf http://irep.iium.edu.my/62641/2/62641_Influence%20of%20hospitalization%20on%20potentially_SCOPUS.pdf http://irep.iium.edu.my/62641/13/62641_Influence%20of%20hospitalization%20on%20potentially_WoS.pdf

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spelling	iium-626412018-10-22T00:31:55Z http://irep.iium.edu.my/62641/ Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki RS Pharmacy and materia medica Purpose: To compare the prevalence and type of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) on admission and discharge of patients, and to determine the associated predictors. Methods: This was a prospective observational study conducted in the multidisciplinary medical and surgical units of Hospital Tengku Ampuan Afzan (HTAA), Malaysia. The medications of patients who had been admitted to the hospital from community-dwelling settings were reviewed to identify PIMs/PPOs using version 2 of STOPP/START criteria. A logistic regression model was applied to detect the risk factors associated with PIM or PPO at discharge. Results: Among the 300 patients involved in the study, the prevalence of PIMs was 27 % upon admission, which decreased to 22.3 % at discharge (p = 0.014) with PIMs pertaining to increasing the risk of physical falls in elderly people being the most common for pre- and post-hospitalization. The prevalence of PPOs was 47.6 % upon admission, which increased to 48 % at discharge (p = 0.99), with the omission of musculoskeletal medications being the most common PPOs at admission and discharge. Having a PIM at discharge was associated with the number of discharge medications and the history of falls, whereas having a high comorbidity index score or history of falls was associated with having a PPO at discharge. Conclusion: Hospitalization significantly reduces the prevalence of PIMs, but not PPOs or polypharmacy, among elderly patients. The number of discharge medications and the history of falls are predictors of discharge PIM, whilst high comorbidities and the history of falls were the predictors of discharge PPO. Improving the knowledge of hospital practitioners regarding geriatric pharmacotherapy is required to optimize prescribing in elderly patients during hospitalization. University of Benin 2018-01-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62641/1/62641_Influence%20of%20hospitalization%20on%20potentially.pdf application/pdf en http://irep.iium.edu.my/62641/2/62641_Influence%20of%20hospitalization%20on%20potentially_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/62641/13/62641_Influence%20of%20hospitalization%20on%20potentially_WoS.pdf Akkawi, Muhammad Eid and Nik Mohamed, Mohamad Haniki (2018) Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community. Tropical Journal of Pharmaceutical Research, 17 (1). pp. 151-160. ISSN 1596-5996 E-ISSN 1596-9827 https://www.ajol.info/index.php/tjpr/article/view/166858 10.4314/tjpr.v17i1.21
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
description	Purpose: To compare the prevalence and type of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) on admission and discharge of patients, and to determine the associated predictors. Methods: This was a prospective observational study conducted in the multidisciplinary medical and surgical units of Hospital Tengku Ampuan Afzan (HTAA), Malaysia. The medications of patients who had been admitted to the hospital from community-dwelling settings were reviewed to identify PIMs/PPOs using version 2 of STOPP/START criteria. A logistic regression model was applied to detect the risk factors associated with PIM or PPO at discharge. Results: Among the 300 patients involved in the study, the prevalence of PIMs was 27 % upon admission, which decreased to 22.3 % at discharge (p = 0.014) with PIMs pertaining to increasing the risk of physical falls in elderly people being the most common for pre- and post-hospitalization. The prevalence of PPOs was 47.6 % upon admission, which increased to 48 % at discharge (p = 0.99), with the omission of musculoskeletal medications being the most common PPOs at admission and discharge. Having a PIM at discharge was associated with the number of discharge medications and the history of falls, whereas having a high comorbidity index score or history of falls was associated with having a PPO at discharge. Conclusion: Hospitalization significantly reduces the prevalence of PIMs, but not PPOs or polypharmacy, among elderly patients. The number of discharge medications and the history of falls are predictors of discharge PIM, whilst high comorbidities and the history of falls were the predictors of discharge PPO. Improving the knowledge of hospital practitioners regarding geriatric pharmacotherapy is required to optimize prescribing in elderly patients during hospitalization.
format	Article
author	Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki
author_facet	Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki
author_sort	Akkawi, Muhammad Eid
title	Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
title_short	Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
title_full	Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
title_fullStr	Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
title_full_unstemmed	Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community
title_sort	influence of hospitalization on potentially inappropriate prescribing among elderly patients in a malaysian community
publisher	University of Benin
publishDate	2018
url	http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/ http://irep.iium.edu.my/62641/1/62641_Influence%20of%20hospitalization%20on%20potentially.pdf http://irep.iium.edu.my/62641/2/62641_Influence%20of%20hospitalization%20on%20potentially_SCOPUS.pdf http://irep.iium.edu.my/62641/13/62641_Influence%20of%20hospitalization%20on%20potentially_WoS.pdf
first_indexed	2023-09-18T21:28:46Z
last_indexed	2023-09-18T21:28:46Z
_version_	1777412369058627584

Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community

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