An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

Background: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. Material...

Full description

Bibliographic Details
Main Authors:	Das, Sreemoy Kanti, Sengupta, Pinaki, Mustapha, Mohd Shahimi, Sarker, Md Moklesur Rahman
Format:	Article
Language:	English English English
Published:	Medknow Publications 2017
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/1/62715_An%20experimental%20evaluation%20of%20adaptogenic%20potential_article.pdf http://irep.iium.edu.my/62715/7/62715_An%20experimental%20evaluation%20of%20adaptogenic_scopus.pdf http://irep.iium.edu.my/62715/13/62715_An%20experimental%20evaluation%20of%20adaptogenic.pdf

id	iium-62715
recordtype	eprints
spelling	iium-627152018-04-06T06:57:25Z http://irep.iium.edu.my/62715/ An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract Das, Sreemoy Kanti Sengupta, Pinaki Mustapha, Mohd Shahimi Sarker, Md Moklesur Rahman RM Therapeutics. Pharmacology Background: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. Materials and Methods: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E.aureumextract. Diazepam (5 mg/kg) was taken as a reference standard. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as noninvasive biomarkers to assess the anti-stress activity and plasma cortisol, blood ascorbic acid, and weight of adrenal were measured. The 24 h urinary excretion of VMA and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The hematological parameters (neutrophils, lymphocytes, and eosinophils) were also determined. Results: Administration of E.aureumat doses of 400 and 600 mg/kg wasfound to be effective in inhibiting the stress induced urinary biochemical changes in a dose-dependent manner. Treatment with E. aureum extract prevents the rise in blood ascorbic acid and plasma cortisol. Moreover, the extract prevented the increase in weight of adrenal gland also significantly increased the anoxia stress tolerance time. Dose-dependent significant reduction in white blood cell count was observed in anoxic stress tolerance test as compared to stressed group. Conclusion: Hence, the present study provides scientific support for the positiveadaptogenic effect of E. aureum extract. Medknow Publications 2017-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62715/1/62715_An%20experimental%20evaluation%20of%20adaptogenic%20potential_article.pdf application/pdf en http://irep.iium.edu.my/62715/7/62715_An%20experimental%20evaluation%20of%20adaptogenic_scopus.pdf application/pdf en http://irep.iium.edu.my/62715/13/62715_An%20experimental%20evaluation%20of%20adaptogenic.pdf Das, Sreemoy Kanti and Sengupta, Pinaki and Mustapha, Mohd Shahimi and Sarker, Md Moklesur Rahman (2017) An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract. Journal of Pharmacy and Bioallied Sciences, 9 (2 (April-June)). pp. 88-93. ISSN 0976-4879 E-ISSN 0975-7406 http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=2;spage=88;epage=93;aulast=Das 10.4103/0975-7406.183227
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Das, Sreemoy Kanti Sengupta, Pinaki Mustapha, Mohd Shahimi Sarker, Md Moklesur Rahman An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
description	Background: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. Materials and Methods: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E.aureumextract. Diazepam (5 mg/kg) was taken as a reference standard. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as noninvasive biomarkers to assess the anti-stress activity and plasma cortisol, blood ascorbic acid, and weight of adrenal were measured. The 24 h urinary excretion of VMA and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The hematological parameters (neutrophils, lymphocytes, and eosinophils) were also determined. Results: Administration of E.aureumat doses of 400 and 600 mg/kg wasfound to be effective in inhibiting the stress induced urinary biochemical changes in a dose-dependent manner. Treatment with E. aureum extract prevents the rise in blood ascorbic acid and plasma cortisol. Moreover, the extract prevented the increase in weight of adrenal gland also significantly increased the anoxia stress tolerance time. Dose-dependent significant reduction in white blood cell count was observed in anoxic stress tolerance test as compared to stressed group. Conclusion: Hence, the present study provides scientific support for the positiveadaptogenic effect of E. aureum extract.
format	Article
author	Das, Sreemoy Kanti Sengupta, Pinaki Mustapha, Mohd Shahimi Sarker, Md Moklesur Rahman
author_facet	Das, Sreemoy Kanti Sengupta, Pinaki Mustapha, Mohd Shahimi Sarker, Md Moklesur Rahman
author_sort	Das, Sreemoy Kanti
title	An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
title_short	An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
title_full	An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
title_fullStr	An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
title_full_unstemmed	An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
title_sort	experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract
publisher	Medknow Publications
publishDate	2017
url	http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/ http://irep.iium.edu.my/62715/1/62715_An%20experimental%20evaluation%20of%20adaptogenic%20potential_article.pdf http://irep.iium.edu.my/62715/7/62715_An%20experimental%20evaluation%20of%20adaptogenic_scopus.pdf http://irep.iium.edu.my/62715/13/62715_An%20experimental%20evaluation%20of%20adaptogenic.pdf
first_indexed	2023-09-18T21:28:51Z
last_indexed	2023-09-18T21:28:51Z
_version_	1777412374934847488

An experimental evaluation of adaptogenic potential of standardized epipremnum aureum leaf extract

Similar Items