Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
Rapid development in technology and society has generated diverse developments in many fields including biosensors in healthcare application. Here, the design of integrated biosensor comprises mass sensing (Quartz Crystal Microbalance) and electrochemistry sensing (Electrochemical Impedance Spe...
| Main Authors: | , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
IEEE
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/1/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated.pdf http://irep.iium.edu.my/62876/2/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated%20SCOPUS.pdf |
| Summary: | Rapid development in technology and society has
generated diverse developments in many fields including
biosensors in healthcare application. Here, the design of
integrated biosensor comprises mass sensing (Quartz Crystal
Microbalance) and electrochemistry sensing (Electrochemical
Impedance Spectroscopy, EIS and Cyclic Voltammetry, CV) will
be presented. The integrated sensor system is developed based on
the innovative use of the top electrode of a quartz crystal
microbalance (QCM) resonator as a working electrode for the
electrochemistry technique. Integration of QCM with the
electrochemistry technique is realized by fabricating a
semicircular counter electrode near the upper electrode on the
same side of the quartz crystal. CV and EIS measurement was
conducted using finite element modeling, COMSOLTM 5.2 with
the probe marker of 1 mmol L−1 of [Fe(CN)6]3−/4−. CV test was
done to study the effect between increasing scan rate and peak
current (anodic and cathodic) in observing the reversible
electrochemical process. This observation is crucial in ensuring
the electrochemical processes follow the Randles-Sevcik equation
in characterizing the platform changes behavior. Later, EIS test
was performed in order to measure the radius of the semicircle
which reflects the charge transfer resistance (RCT) of the redox
marker. To show the effectiveness of this sensor, gold
immobilization surface was electrochemically simulated and
reported. Thus, an ultra-sensitive biosensor that capable to
produce multi-analysis in the detection of biological targets in
terms of electrochemical change of electrode interfaces, which is
the crucial step towards the engineering of advanced
bioelectronics. |
|---|