Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities

Rapid development in technology and society has generated diverse developments in many fields including biosensors in healthcare application. Here, the design of integrated biosensor comprises mass sensing (Quartz Crystal Microbalance) and electrochemistry sensing (Electrochemical Impedance Spe...

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Main Authors:	Zainuddin, Ahmad Anwar, Nordin, Anis Nurashikin, Ab Rahim, Rosminazuin, Mak, Wing Cheung
Format:	Conference or Workshop Item
Language:	English English
Published:	IEEE 2017
Subjects:	T Technology (General)
Online Access:	http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/1/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated.pdf http://irep.iium.edu.my/62876/2/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated%20SCOPUS.pdf

id	iium-62876
recordtype	eprints
spelling	iium-628762018-07-10T05:44:14Z http://irep.iium.edu.my/62876/ Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities Zainuddin, Ahmad Anwar Nordin, Anis Nurashikin Ab Rahim, Rosminazuin Mak, Wing Cheung T Technology (General) Rapid development in technology and society has generated diverse developments in many fields including biosensors in healthcare application. Here, the design of integrated biosensor comprises mass sensing (Quartz Crystal Microbalance) and electrochemistry sensing (Electrochemical Impedance Spectroscopy, EIS and Cyclic Voltammetry, CV) will be presented. The integrated sensor system is developed based on the innovative use of the top electrode of a quartz crystal microbalance (QCM) resonator as a working electrode for the electrochemistry technique. Integration of QCM with the electrochemistry technique is realized by fabricating a semicircular counter electrode near the upper electrode on the same side of the quartz crystal. CV and EIS measurement was conducted using finite element modeling, COMSOLTM 5.2 with the probe marker of 1 mmol L−1 of [Fe(CN)6]3−/4−. CV test was done to study the effect between increasing scan rate and peak current (anodic and cathodic) in observing the reversible electrochemical process. This observation is crucial in ensuring the electrochemical processes follow the Randles-Sevcik equation in characterizing the platform changes behavior. Later, EIS test was performed in order to measure the radius of the semicircle which reflects the charge transfer resistance (RCT) of the redox marker. To show the effectiveness of this sensor, gold immobilization surface was electrochemically simulated and reported. Thus, an ultra-sensitive biosensor that capable to produce multi-analysis in the detection of biological targets in terms of electrochemical change of electrode interfaces, which is the crucial step towards the engineering of advanced bioelectronics. IEEE 2017-02-06 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/62876/1/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated.pdf application/pdf en http://irep.iium.edu.my/62876/2/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated%20SCOPUS.pdf Zainuddin, Ahmad Anwar and Nordin, Anis Nurashikin and Ab Rahim, Rosminazuin and Mak, Wing Cheung (2017) Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities. In: 2016 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES), 4th-8th December 2016, Kuala Lumpur, Malaysia. http://ieeexplore.ieee.org/document/7843485/ 10.1109/IECBES.2016.7843485
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	T Technology (General)
spellingShingle	T Technology (General) Zainuddin, Ahmad Anwar Nordin, Anis Nurashikin Ab Rahim, Rosminazuin Mak, Wing Cheung Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
description	Rapid development in technology and society has generated diverse developments in many fields including biosensors in healthcare application. Here, the design of integrated biosensor comprises mass sensing (Quartz Crystal Microbalance) and electrochemistry sensing (Electrochemical Impedance Spectroscopy, EIS and Cyclic Voltammetry, CV) will be presented. The integrated sensor system is developed based on the innovative use of the top electrode of a quartz crystal microbalance (QCM) resonator as a working electrode for the electrochemistry technique. Integration of QCM with the electrochemistry technique is realized by fabricating a semicircular counter electrode near the upper electrode on the same side of the quartz crystal. CV and EIS measurement was conducted using finite element modeling, COMSOLTM 5.2 with the probe marker of 1 mmol L−1 of [Fe(CN)6]3−/4−. CV test was done to study the effect between increasing scan rate and peak current (anodic and cathodic) in observing the reversible electrochemical process. This observation is crucial in ensuring the electrochemical processes follow the Randles-Sevcik equation in characterizing the platform changes behavior. Later, EIS test was performed in order to measure the radius of the semicircle which reflects the charge transfer resistance (RCT) of the redox marker. To show the effectiveness of this sensor, gold immobilization surface was electrochemically simulated and reported. Thus, an ultra-sensitive biosensor that capable to produce multi-analysis in the detection of biological targets in terms of electrochemical change of electrode interfaces, which is the crucial step towards the engineering of advanced bioelectronics.
format	Conference or Workshop Item
author	Zainuddin, Ahmad Anwar Nordin, Anis Nurashikin Ab Rahim, Rosminazuin Mak, Wing Cheung
author_facet	Zainuddin, Ahmad Anwar Nordin, Anis Nurashikin Ab Rahim, Rosminazuin Mak, Wing Cheung
author_sort	Zainuddin, Ahmad Anwar
title	Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
title_short	Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
title_full	Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
title_fullStr	Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
title_full_unstemmed	Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
title_sort	modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities
publisher	IEEE
publishDate	2017
url	http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/ http://irep.iium.edu.my/62876/1/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated.pdf http://irep.iium.edu.my/62876/2/62876%20Modeling%20of%20a%20Novel%20Biosensor%20with%20Integrated%20SCOPUS.pdf
first_indexed	2023-09-18T21:29:06Z
last_indexed	2023-09-18T21:29:06Z
_version_	1777412390144442368

Modeling of a novel biosensor with integrated mass and electrochemical sensing capabilities

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