Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...

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Main Authors:	Awaad, Amani Shafeek, Alafeefy, Ahmed Mahmoud, Alasmary, Fatmah A.S., El-Meligy, Reham M., Zain, Mohamed E., Alqasoumi, Saleh Ibrahim
Format:	Article
Language:	English English
Published:	King Saud University 2017
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf

id	iium-62988
recordtype	eprints
spelling	iium-629882018-06-21T02:44:29Z http://irep.iium.edu.my/62988/ Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim Q Science (General) QD Chemistry A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. King Saud University 2017-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf application/pdf en http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf Awaad, Amani Shafeek and Alafeefy, Ahmed Mahmoud and Alasmary, Fatmah A.S. and El-Meligy, Reham M. and Zain, Mohamed E. and Alqasoumi, Saleh Ibrahim (2017) Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity. Saudi Pharmaceutical Journal, 25 (7). pp. 967-971. ISSN 1319-0164 https://ac.els-cdn.com/S1319016417300336/1-s2.0-S1319016417300336-main.pdf?_tid=65296070-a4b4-4070-87ff-74fafe7351e2&acdnat=1521772234_e894eeedbc735db615b2bce506872115 10.1016/j.jsps.2017.02.012
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
description	A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging.
format	Article
author	Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim
author_facet	Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim
author_sort	Awaad, Amani Shafeek
title	Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_short	Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_full	Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_fullStr	Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_full_unstemmed	Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_sort	novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
publisher	King Saud University
publishDate	2017
url	http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf
first_indexed	2023-09-18T21:29:17Z
last_indexed	2023-09-18T21:29:17Z
_version_	1777412401904222208

Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

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