The need for restructuring the disordered science of amorphous drug formulations

The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-base...

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Main Authors:	Edueng, Khadijah, Mahlin, Denny, Bergström, Christel A.S.
Format:	Article
Language:	English English
Published:	Springer New York LLC 2017
Subjects:	RS Pharmacy and materia medica T Technology (General)
Online Access:	http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/1/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_article.pdf http://irep.iium.edu.my/63090/2/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_scopus.pdf

id	iium-63090
recordtype	eprints
spelling	iium-630902018-04-18T04:07:33Z http://irep.iium.edu.my/63090/ The need for restructuring the disordered science of amorphous drug formulations Edueng, Khadijah Mahlin, Denny Bergström, Christel A.S. RS Pharmacy and materia medica T Technology (General) The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses of old experimental methods and how they can be used in tandem with computational tools in designing amorphous formulation more efficiently than the traditional trial-and-error approach. Springer New York LLC 2017-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63090/1/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_article.pdf application/pdf en http://irep.iium.edu.my/63090/2/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_scopus.pdf Edueng, Khadijah and Mahlin, Denny and Bergström, Christel A.S. (2017) The need for restructuring the disordered science of amorphous drug formulations. Pharmaceutical Research, 34 (9). pp. 1754-1772. ISSN 0724-8741 E-ISSN 1573-904X https://link.springer.com/article/10.1007/s11095-017-2174-7 10.1007/s11095-017-2174-7
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica T Technology (General)
spellingShingle	RS Pharmacy and materia medica T Technology (General) Edueng, Khadijah Mahlin, Denny Bergström, Christel A.S. The need for restructuring the disordered science of amorphous drug formulations
description	The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses of old experimental methods and how they can be used in tandem with computational tools in designing amorphous formulation more efficiently than the traditional trial-and-error approach.
format	Article
author	Edueng, Khadijah Mahlin, Denny Bergström, Christel A.S.
author_facet	Edueng, Khadijah Mahlin, Denny Bergström, Christel A.S.
author_sort	Edueng, Khadijah
title	The need for restructuring the disordered science of amorphous drug formulations
title_short	The need for restructuring the disordered science of amorphous drug formulations
title_full	The need for restructuring the disordered science of amorphous drug formulations
title_fullStr	The need for restructuring the disordered science of amorphous drug formulations
title_full_unstemmed	The need for restructuring the disordered science of amorphous drug formulations
title_sort	need for restructuring the disordered science of amorphous drug formulations
publisher	Springer New York LLC
publishDate	2017
url	http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/ http://irep.iium.edu.my/63090/1/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_article.pdf http://irep.iium.edu.my/63090/2/63090_The%20Need%20for%20Restructuring%20the%20Disordered%20Science_scopus.pdf
first_indexed	2023-09-18T21:29:29Z
last_indexed	2023-09-18T21:29:29Z
_version_	1777412415096356864

The need for restructuring the disordered science of amorphous drug formulations

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