Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity

Two novel quinazoline derivatives named as; 3-[(4-hydroxy-3-methoxy-benzylidene)-amino]-2-p-tolyl3H-quinazolin-4-one (5) and 2-p-Tolyl-3-[3,4,5-trimethoxy-benzylidene-amino]-3H-quinazolin-4-one (6) in addition to one acetamide derivative named as 2-(2-Hydroxycarbonylphenylamino)-N-(4- aminosulpho...

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Main Authors:	Alasmary, Fatmah A.S., Awaad, Amani Shafeek, Alafeefy, Ahmed Mahmoud, El-Meligy, Reham M., Alqasoumi, Saleh Ibrahim
Format:	Article
Language:	English English English
Published:	Elsevier 2018
Subjects:	T Technology (General)
Online Access:	http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/1/63145-%20Novel%20quinazoline%20and%20acetamide%20derivatives%20as%20safe%20anti-ulcerogenic.pdf http://irep.iium.edu.my/63145/19/55862%20Novel%20quinazoline%20and%20acetamide%20SCOPUS.pdf http://irep.iium.edu.my/63145/13/63145_Novel%20quinazoline%20and%20acetamide%20derivatives_wos.pdf

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spelling	iium-631452019-01-30T00:49:47Z http://irep.iium.edu.my/63145/ Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity Alasmary, Fatmah A.S. Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim T Technology (General) Two novel quinazoline derivatives named as; 3-[(4-hydroxy-3-methoxy-benzylidene)-amino]-2-p-tolyl3H-quinazolin-4-one (5) and 2-p-Tolyl-3-[3,4,5-trimethoxy-benzylidene-amino]-3H-quinazolin-4-one (6) in addition to one acetamide derivative named as 2-(2-Hydroxycarbonylphenylamino)-N-(4- aminosulphonylphenyl) 11 were synthesized, and evaluated for their anti-ulcerogenic & AntiUlcerative colitis activities. All of the three compounds showed curative activity against acetic acid induced ulcer model at a dose of 50 mg/kg, they produced 65%, 85% & 57.74% curative ratio for compounds 5, 6 & 11 respectively. The effect of the tested compounds 5, 6 & 11 at dose 50 mg/kg were significantly (P < 0.01) more effective than dexamesathone (0.1 mg/kg) in reducing all parameters. Compounds showed curative activity of for peptic ulcer (induced by absolute alcohol (at a dose of 50 mg/kg, it produced Curative of control ulcer 56.00%, 61.70% & 87.1% for compounds 5, 6 & 11 respectively at dose 50 mg/kg, while the standard drug (Omeprazole 20 mg/kg) produced 33.3%. In both tests, the activity of our target compounds were higher than the standard drugs used for treatment of peptic ulcer and ulcerative colitis. No side effects were reported on liver and kidney functions upon prolonged oral administration of this compounds. Elsevier 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63145/1/63145-%20Novel%20quinazoline%20and%20acetamide%20derivatives%20as%20safe%20anti-ulcerogenic.pdf application/pdf en http://irep.iium.edu.my/63145/19/55862%20Novel%20quinazoline%20and%20acetamide%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/63145/13/63145_Novel%20quinazoline%20and%20acetamide%20derivatives_wos.pdf Alasmary, Fatmah A.S. and Awaad, Amani Shafeek and Alafeefy, Ahmed Mahmoud and El-Meligy, Reham M. and Alqasoumi, Saleh Ibrahim (2018) Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity. Saudi Pharmaceutical Journal, 26 (1). pp. 138-143. ISSN 1319-0164 https://ac.els-cdn.com/S1319016417301676/1-s2.0-S1319016417301676-main.pdf?_tid=8c31153c-8e3d-4c0f-922b-c96299d9e215&acdnat=1522114348_d2a12a36aa8688eedf102b32855f6f72 10.1016/j.jsps.2017.09.011
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	T Technology (General)
spellingShingle	T Technology (General) Alasmary, Fatmah A.S. Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
description	Two novel quinazoline derivatives named as; 3-[(4-hydroxy-3-methoxy-benzylidene)-amino]-2-p-tolyl3H-quinazolin-4-one (5) and 2-p-Tolyl-3-[3,4,5-trimethoxy-benzylidene-amino]-3H-quinazolin-4-one (6) in addition to one acetamide derivative named as 2-(2-Hydroxycarbonylphenylamino)-N-(4- aminosulphonylphenyl) 11 were synthesized, and evaluated for their anti-ulcerogenic & AntiUlcerative colitis activities. All of the three compounds showed curative activity against acetic acid induced ulcer model at a dose of 50 mg/kg, they produced 65%, 85% & 57.74% curative ratio for compounds 5, 6 & 11 respectively. The effect of the tested compounds 5, 6 & 11 at dose 50 mg/kg were significantly (P < 0.01) more effective than dexamesathone (0.1 mg/kg) in reducing all parameters. Compounds showed curative activity of for peptic ulcer (induced by absolute alcohol (at a dose of 50 mg/kg, it produced Curative of control ulcer 56.00%, 61.70% & 87.1% for compounds 5, 6 & 11 respectively at dose 50 mg/kg, while the standard drug (Omeprazole 20 mg/kg) produced 33.3%. In both tests, the activity of our target compounds were higher than the standard drugs used for treatment of peptic ulcer and ulcerative colitis. No side effects were reported on liver and kidney functions upon prolonged oral administration of this compounds.
format	Article
author	Alasmary, Fatmah A.S. Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim
author_facet	Alasmary, Fatmah A.S. Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim
author_sort	Alasmary, Fatmah A.S.
title	Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
title_short	Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
title_full	Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
title_fullStr	Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
title_full_unstemmed	Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
title_sort	novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
publisher	Elsevier
publishDate	2018
url	http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/ http://irep.iium.edu.my/63145/1/63145-%20Novel%20quinazoline%20and%20acetamide%20derivatives%20as%20safe%20anti-ulcerogenic.pdf http://irep.iium.edu.my/63145/19/55862%20Novel%20quinazoline%20and%20acetamide%20SCOPUS.pdf http://irep.iium.edu.my/63145/13/63145_Novel%20quinazoline%20and%20acetamide%20derivatives_wos.pdf
first_indexed	2023-09-18T21:29:36Z
last_indexed	2023-09-18T21:29:36Z
_version_	1777412421603819520

Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity

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