Model of critical size defect in the New Zealand White rabbit's tibia
Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf |
| Summary: | Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus
cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new
bone substitute material. There are varieties of protocols available in the literature. This technical note
attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia.
Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm
(width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from
the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable
surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed
tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding
from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks
and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was
demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits. |
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