Model of critical size defect in the New Zealand White rabbit's tibia

Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature....

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Main Authors:	Che Seman, Che Nor Zarida, Zakaria@Mohamad, Zamzuri, Sharifudin, Mohd Ariff, Che Ahmad, Aminudin, Awang, Mohd Shukrimi, Mohd Yusof, Nazri, Buyong, Zunariah
Format:	Article
Language:	English English English
Published:	2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf

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spelling	iium-632582018-10-31T06:17:43Z http://irep.iium.edu.my/63258/ Model of critical size defect in the New Zealand White rabbit's tibia Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah R Medicine (General) Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits. 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf application/pdf en http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf application/pdf en http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Sharifudin, Mohd Ariff and Che Ahmad, Aminudin and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2018) Model of critical size defect in the New Zealand White rabbit's tibia. The International Medical Journal Malaysia, 17 (1). pp. 13-18. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah Model of critical size defect in the New Zealand White rabbit's tibia
description	Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits.
format	Article
author	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah
author_facet	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah
author_sort	Che Seman, Che Nor Zarida
title	Model of critical size defect in the New Zealand White rabbit's tibia
title_short	Model of critical size defect in the New Zealand White rabbit's tibia
title_full	Model of critical size defect in the New Zealand White rabbit's tibia
title_fullStr	Model of critical size defect in the New Zealand White rabbit's tibia
title_full_unstemmed	Model of critical size defect in the New Zealand White rabbit's tibia
title_sort	model of critical size defect in the new zealand white rabbit's tibia
publishDate	2018
url	http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf
first_indexed	2023-09-18T21:29:43Z
last_indexed	2023-09-18T21:29:43Z
_version_	1777412429390544896

Model of critical size defect in the New Zealand White rabbit's tibia

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