Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method

The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of mefenamic acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the e...

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Main Authors:	Zolkepali, Nurul Karimah, Abu Bakar, Noor Fitrah, Naim, M. Nazli, Anuar, Nornizar, Kamalul Aripin, Nurul Fadhilah, Abu Bakar, Mohd Rushdi, Lenggoro, I. Wuled, Kamiya, Hidehiro
Format:	Article
Language:	English English English English
Published:	Taylor & Francis 2018
Subjects:	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering
Online Access:	http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/1/2016_Rushdi_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid.pdf http://irep.iium.edu.my/63406/13/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles_article.pdf http://irep.iium.edu.my/63406/7/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid_SCOPUS.pdf http://irep.iium.edu.my/63406/19/63406%20Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles%20for%20dissolution%20improvement%20via%20electrospray%20method_wos.pdf

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spelling	iium-634062019-01-24T04:11:55Z http://irep.iium.edu.my/63406/ Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, M. Nazli Anuar, Nornizar Kamalul Aripin, Nurul Fadhilah Abu Bakar, Mohd Rushdi Lenggoro, I. Wuled Kamiya, Hidehiro RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of mefenamic acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the electrospray process to atomize the droplet into fine dried particles. The working distance (WD) between the electrospray needle tip and the substrate were varied from 15 to 25 cm. The sizes of encapsulated MA-βCD particles were found to decrease from 91 +- 26 to 42 +- 35 nm as the WD increased. The dissolution rate of encapsulated particles of MA-βCD was found to be higher compared to the particles of as-received MA and the unencapsulated MA. The presence of the encapsulated MA-βCD was proven by a thermal analysis with the disappearance of MA peak after the atomization process. The x-ray diffraction and FTIR analysis showed that the encapsulation occurred with the existence of new solid phase that was expected from interaction between MA and βCD and the appearance of C=C. Further analysis by transmission electron microscopy showed the size and morphology of MA-βCD particles when immersed in water and acetone. Encapsulated MA-βCD particles were solubilized in water but suspended as spherical shape in acetone. Taylor & Francis 2018-04-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63406/1/2016_Rushdi_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid.pdf application/pdf en http://irep.iium.edu.my/63406/13/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles_article.pdf application/pdf en http://irep.iium.edu.my/63406/7/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/63406/19/63406%20Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles%20for%20dissolution%20improvement%20via%20electrospray%20method_wos.pdf Zolkepali, Nurul Karimah and Abu Bakar, Noor Fitrah and Naim, M. Nazli and Anuar, Nornizar and Kamalul Aripin, Nurul Fadhilah and Abu Bakar, Mohd Rushdi and Lenggoro, I. Wuled and Kamiya, Hidehiro (2018) Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method. Particulate Science and Technology, 36 (3). pp. 298-307. ISSN 0272-6351 E-ISSN 1548-0046 https://www.tandfonline.com/doi/abs/10.1080/02726351.2016.1246496?journalCode=upst20 10.1080/02726351.2016.1246496
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, M. Nazli Anuar, Nornizar Kamalul Aripin, Nurul Fadhilah Abu Bakar, Mohd Rushdi Lenggoro, I. Wuled Kamiya, Hidehiro Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
description	The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of mefenamic acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the electrospray process to atomize the droplet into fine dried particles. The working distance (WD) between the electrospray needle tip and the substrate were varied from 15 to 25 cm. The sizes of encapsulated MA-βCD particles were found to decrease from 91 +- 26 to 42 +- 35 nm as the WD increased. The dissolution rate of encapsulated particles of MA-βCD was found to be higher compared to the particles of as-received MA and the unencapsulated MA. The presence of the encapsulated MA-βCD was proven by a thermal analysis with the disappearance of MA peak after the atomization process. The x-ray diffraction and FTIR analysis showed that the encapsulation occurred with the existence of new solid phase that was expected from interaction between MA and βCD and the appearance of C=C. Further analysis by transmission electron microscopy showed the size and morphology of MA-βCD particles when immersed in water and acetone. Encapsulated MA-βCD particles were solubilized in water but suspended as spherical shape in acetone.
format	Article
author	Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, M. Nazli Anuar, Nornizar Kamalul Aripin, Nurul Fadhilah Abu Bakar, Mohd Rushdi Lenggoro, I. Wuled Kamiya, Hidehiro
author_facet	Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, M. Nazli Anuar, Nornizar Kamalul Aripin, Nurul Fadhilah Abu Bakar, Mohd Rushdi Lenggoro, I. Wuled Kamiya, Hidehiro
author_sort	Zolkepali, Nurul Karimah
title	Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
title_short	Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
title_full	Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
title_fullStr	Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
title_full_unstemmed	Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method
title_sort	formation of fine and encapsulated mefenamic acid form i particles for dissolution improvement via electrospray method
publisher	Taylor & Francis
publishDate	2018
url	http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/ http://irep.iium.edu.my/63406/1/2016_Rushdi_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid.pdf http://irep.iium.edu.my/63406/13/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles_article.pdf http://irep.iium.edu.my/63406/7/63406_Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid_SCOPUS.pdf http://irep.iium.edu.my/63406/19/63406%20Formation%20of%20fine%20and%20encapsulated%20mefenamic%20acid%20form%20I%20particles%20for%20dissolution%20improvement%20via%20electrospray%20method_wos.pdf
first_indexed	2023-09-18T21:29:56Z
last_indexed	2023-09-18T21:29:56Z
_version_	1777412442739965952

Formation of fine and encapsulated mefenamic acid form I particles for dissolution improvement via electrospray method

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